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The Importance of Dimensional Traceability in Microfluidic Systems

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Dimensional measurements are fundamental in microfluidic device manufacturing and performance. The main focus of this study is the measurement of the connection port sizes in microfluidic devices and components and, accordingly, the possible existence of fluid leaks determined using the flow rate error. The sizes associated with three different microfluidic systems were determined using laser interferometry and through an optical measuring instrument, with metrological traceability to national length standards. It was possible to infer the method with the greatest accuracy and lowest measurement uncertainty for characterizing this kind of system. In conclusion, the results of this work directly address the current lack of dimensions measuring methods of microfluidic components by providing a comprehensive comparison of different protocols, ultimately suggesting a preferred option for immediate application within the microfluidic industry.

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Funding Information: This work was performed under project 20NRM02 MFMET that has received funding from the EMPIR program co-financed by the participating States and from the European Union\u2019s Horizon 2020 research and innovation program. Funding Information: This project (20NRM02 MFMET) has received funding from the EMPIR program co-financed by the Participating States and from the European Union’s Horizon 2020 research and innovation program. The authors would like to thanks to Microfluidic ChipShop, a partner of MFMET project, for providing Topas plates and connectors used in this paper. The authors also acknowledge Fundação para a Ciência e a Tecnologia for its financial support through the UNIDEMI projects UIDB/00667/2020 and UIDP/00667/2020. INESC MN acknowledges FCT for funding of the Research Unit (UID/05367/2020) through pluriannual BASE and PROGRAMATICO and program grant PTDC-FIS-PLA/31055/2017. We would like to thank Olivier Pellegrino from IPQ for is extensive editorial and language revision. Publisher Copyright: © 2024 by the authors.

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dimensional traceability leakage microfluidic Engineering (miscellaneous) Physics and Astronomy (miscellaneous)

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