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Publicação
Population dynamics of centrosome amplification
| Nome: | Descrição: | Tamanho: | Formato: | |
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| 44.61 MB | Adobe PDF |
Autores
Orientador(es)
Resumo(s)
"Living organisms are fundamentally composed of cells and subject
to evolutionary change. These are perhaps two of the most
general concepts in biology. An integrative framework that encompasses
both evolutionary and cell biology is necessary for
understanding how cellular features change and diversify. Such a
framework is crucial for understanding a plethora of phenomena,
ranging from how cellular components expand and disappear
across the tree of life to human disease. In this thesis, I make
use of evolutionary and cell biological principles to address the
causes and consequences of centriole number abnormalities.(...)"
Descrição
Palavras-chave
centrosome amplification mutation-selection balance cancer Plk4 cell cycle