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Orientador(es)
Resumo(s)
RESUMO - O ácido δ-aminolevulínico presente na urina (ALA-U) é
generalizadamente aceite como um indicador adequado
para a vigilância de saúde de trabalhadores expostos a
chumbo. A necessidade ou não de recurso a colheitas de
urina de 24 horas para um correcto doseamento desse
metabolito tem, entretanto, suscitado algumas dúvidas.
Num estudo abrangendo 45 indivíduos (28 dos quais profissionalmente
expostos a chumbo inorgânico) efectuou-se o
doseamento do ALA em urinas colhidas durante 24 horas
e em urina de colheita única.
Confirmou-se a existência de uma boa correlação entre o
ALA urinário e a plumbemia e que o tipo de colheita de
urina efectuada não influencia significativamente essa associação.
Contudo, pela apreciação das variações interindividuais
registadas, parece aconselhável que seja privilegiado
o doseamento em urinas de 24 horas.
ABSTRACT - ALA-U (δ-aminolevulinic acid in urine) is generally accepted as a good biologic biomarker for health surveillance programs of exposed lead workers. The necessity of 24 hours urine samples to measure this metabolite has, in the meantime, suggested some discussion. A study on 45 individuals (28 of them occupationally exposed to lead) has been conducted with measurement of ALA in 24 hours urine samples and in urine of one single sample. A good correlation between ALA-U and blood lead was confirmed, as well as the fact that the method of collecting urine has not significant influence on this association. Nevertheless, the observed inter-individual differences advise the option for the 24 hours samples measurement.
ABSTRACT - ALA-U (δ-aminolevulinic acid in urine) is generally accepted as a good biologic biomarker for health surveillance programs of exposed lead workers. The necessity of 24 hours urine samples to measure this metabolite has, in the meantime, suggested some discussion. A study on 45 individuals (28 of them occupationally exposed to lead) has been conducted with measurement of ALA in 24 hours urine samples and in urine of one single sample. A good correlation between ALA-U and blood lead was confirmed, as well as the fact that the method of collecting urine has not significant influence on this association. Nevertheless, the observed inter-individual differences advise the option for the 24 hours samples measurement.
Descrição
Palavras-chave
Saúde ocupacional Chumbo
Contexto Educativo
Citação
Editora
Escola Nacional de Saúde Pública. Universidade NOVA de Lisboa
