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Publicação
Type I Interferon Response of Brain Endot helial Cells in Cerebral Malaria: Antigen Presentation, Immunoproteosome Activation, Endot helial integrity, and Glucose Metabolism
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Resumo(s)
"Malaria is a life-threatening disease caused by the parasite Plasmodium
species. Despite being a preventable and treatable disease, in 2020,
there were 241 million cases of malaria worldwide. The WHO Africa
region shares a disproportionately higher burden of global malaria.
Among the spectrum of symptoms, cerebral malaria is the deadliest of
all and is responsible for a major fraction of malaria-associated mortality.
Like many other bacteremia and septicemia-like conditions, cerebral
malaria is also an end-organ damage, where the blood-brain barrier
breaks down and an encephalopathy-like condition happens. The role
of immune cells in the pathophysiology of cerebral malaria is well
recognized but the precise contribution of brain endothelial cells
responses is still unexplored. We discovered a connection between the
metabolism of endothelial cells with the immunity responses and
integrity of the endothelial barrier. (...)"
Descrição
Palavras-chave
cerebral malaria (CM) type - 1 interferons ntigen presentation endothelial cells