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Functional, structural and biophysical view of repair of oxidation damaged DNA in bacteria and Man
| Nome: | Descrição: | Tamanho: | Formato: | |
|---|---|---|---|---|
| 7.61 MB | Adobe PDF |
Orientador(es)
Resumo(s)
"Living organisms have developed multiple DNA repair machinery to maintain
genome integrity. One of the most severe damages that can be inflicted on DNA is
oxidation damage. These damages are mainly caused by Reactive Oxygen Species
(ROS) which are generated by endogenous sources, such as byproducts of cellular
processes (e.g., respiration), or exogenous sources (e.g., environmental stressors and
chemicals). Repairing these damages is crucial for genome maintenance and
preventing the accumulation of mutations that can contribute to various diseases in
humans. The main mechanism responsible for the detection and repair of oxidation
damaged bases in DNA is Base Excision Repair (BER).(...)"
Descrição
Palavras-chave
DNA glycosylase Endonuclease III Base Excision Repair (BER) oxidation damage