Effect of ScCO2 on the decontamination of PECs-based cryogels

Bento, Cristiana S. A.; Carrêlo, Henrique; Alarico, Susana; Empadinhas, Nuno; de Sousa, Hermínio C.; Teresa Cidade, Maria; Braga, Mara E. M.

http://hdl.handle.net/10362/162709

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Autores

Bento, Cristiana S. A.

Carrêlo, Henrique

Alarico, Susana

Empadinhas, Nuno

de Sousa, Hermínio C.

Teresa Cidade, Maria

Braga, Mara E. M.

Resumo(s)

Biopolymers present ideal properties to be used in wound dressing solutions. By mixing two oppositely charged macromolecules it is possible to form polyelectrolyte complex (PEC) based cryogels using lyophilization. Their application in the biomedical field is limited due to their sterilization requirements, as conventional methods compromise their physicochemical properties. ScCO2 appears as an alternative method for decontamination. This work assessed several cryogel PEC formulations, chitosan-pectin, gelatine-xanthan gum and alginate-gelatine. PEC formation was confirmed by FTIR and rheological analysis. While steam sterilization compromised cryogels’ chemical and morphological properties, decontamination with scCO2 proved to be a promising method for decontamination of PEC-cryogels, because, similarly to what is observed with hydrogen peroxide, it does not compromise their physicochemical properties.

Descrição

This work was financially supported by Fundação para a Ciência e Tecnologia (FCT), Portugal, in the scope of the project STERILAEROGEL – Green method to prepare sterilised biopolymer-based aerogel (POCI-01-0145-FEDER-032625), the Strategic Projects FCT-MEC PEst-C/EQB/UI0102/2019. Publisher Copyright: © 2023 The Authors