Utilize este identificador para referenciar este registo: http://hdl.handle.net/10362/161166
Título: Estudo de Prevalência de Insuficiência Cardíaca em Portugal (PORTHOS), fundamentação e conceção – um estudo populacional
Outros títulos: Portuguese Heart Failure Prevalence Observational Study (PORTHOS) rationale and design – A population-based study
Autor: Baptista, Rui
Silva Cardoso, José
Canhão, Helena
Maria Rodrigues, Ana
Kislaya, Irina
Franco, Fátima
Bernardo, Filipa
Pimenta, Joana
Mendes, Lígia
Gonçalves, Sara
Teresa Timóteo, Ana
Andrade, Aurora
Moura, Brenda
Fonseca, Cândida
Aguiar, Carlos
Brito, Dulce
Ferreira, Jorge
Filipe Azevedo, Luís
Peres, Marisa
Santos, Paulo
Moraes Sarmento, Pedro
Cernadas, Rui
Santos, Mário
Fontes-Carvalho, Ricardo
Campos Fernandes, Adalberto
Martinho, Hugo
González-Juanatey, José Ramon
Filipe Pereira, Luís
Gil, Victor
Raquel Marques, Cláudia
Almeida, Mário
Pardal, Marisa
Barbosa, Veneranda
Gavina, Cristina
Palavras-chave: Epidemiology
Heart failure
PORTHOS
Portugal
Prevalence
Quality of life
Cardiology and Cardiovascular Medicine
Data: Dez-2023
Resumo: Introduction and objectives: Current epidemiological data on heart failure (HF) in Portugal derives from studies conducted two decades ago. The main aim of this study is to determine HF prevalence in the Portuguese population. Using current standards, this manuscript aims to describe the methodology and research protocol applied. Methods: The Portuguese Heart Failure Prevalence Observational Study (PORTHOS) is a large, three-stage, population-based, nationwide, cross-sectional study. Community-dwelling citizens aged 50 years and older will be randomly selected via stratified multistage sampling. Eligible participants will be invited to attend a screening visit at a mobile clinic for HF symptom assessment, anthropomorphic assessment, N-terminal pro-B-type natriuretic peptide (NT-proBNP) testing, one-lead electrocardiogram (ECG) and a sociodemographic and health-related quality of life questionnaire (EQ-5D). All subjects with NT-proBNP ≥125 pg/mL or with a prior history of HF will undergo a diagnostic confirmatory assessment at the mobile clinic composed of a 12-lead ECG, comprehensive echocardiography, HF questionnaire (KCCQ) and blood sampling. To validate the screening procedure, a control group will undergo the same diagnostic assessment. Echocardiography results will be centrally validated, and HF diagnosis will be established according to the European Society of Cardiology HF guidelines. A random subsample of patients with an equivocal HF with preserved ejection fraction diagnosis based on the application of the Heart Failure Association preserved ejection fraction diagnostic algorithm will be invited to undergo an exercise echocardiography. Conclusions: Through the application of current standards, appropriate methodologies, and a strong research protocol, the PORTHOS study will determine the prevalence of HF in mainland Portugal and enable a comprehensive characterization of HF patients, leading to a better understanding of their clinical profile and health-related quality of life.
Descrição: Funding Information: PORTHOS study arises from a scientific partnership between the Portuguese Society of Cardiology, AstraZeneca and NOVA Medical School. The authors are especially grateful to all the institutional partners that collaborated at various levels: Associação de Apoio aos Doentes com Insuficiência Cardíaca (AADIC), GlobalSports, Maria Design, Missão Continente (Sonae), Unilabs and GE. For the collaboration in the pilot study, the authors are grateful to Unidade Local de Saúde de Matosinhos (Dr. Nuno Moreno and Dr. Daniel Seabra) and to Câmara Municipal de Matosinhos. We are also grateful to Prof. Artur Paiva and Dr. João Mariano Pêgo from Centro Hospitalar and Universitário de Coimbra. To the members of the study management team for their valuable contribute: Dra. Adriana Salgueiro and Dr. Diogo Pedroso. Publisher Copyright: © 2023 Sociedade Portuguesa de Cardiologia
Peer review: yes
URI: http://hdl.handle.net/10362/161166
DOI: https://doi.org/10.1016/j.repc.2023.10.004
ISSN: 0870-2551
Aparece nas colecções:NMS: CHRC - Artigos em revista internacional com arbitragem científica

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