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In vitro tools to explore cardiac fibrosis target space
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Cardiac fibrosis is driven by activation of cardiac fibroblasts. To date, there are no effective therapies for this disease, which affects many lives, especially patients with cardiovascular disease. This lack of therapeutic options is due to the fact that there are few selective markers for activated cardiac fibroblasts. The aim of this work is to expand the number of selective markers and discover new ligands for the activated state of cardiac fibroblasts. We have studied the transcriptomic and proteomic changes on cardiac fibroblasts upon activation, investigated the impact of using different cell systems in whole-cell phage display selections and performed phage display selections directly in an in vitro model of cardiac fibroblasts.
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fibrosis fibroblasts antibodies phage display