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Regulation of bacterial haem biosynthesis
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Resumo(s)
Haem b and sirohaem are two iron-chelated modified tetrapyrroles that serve as prosthetic groups in proteins with crucial roles in a variety of biological functions, such as gas transport, respiration, and nitrite and sulphite reduction. These tetrapyrroles are synthesised from 5-aminolaevulinic acid and share a common pathway until the formation of uroporphyrinogen III, from where the synthesis diverges. In bacteria, sirohaem is produced from uroporphyrinogen III through the activities of one, two or three separate proteins, while haem b is synthesised through three distinct pathways. The biosynthesis of haem b and sirohaem comprises intermediates and end-products that are unstable or potentially hazardous to the cell. Therefore, the cellular metabolic fluxes of tetrapyrroles need to be tightly controlled by substrate channelling and/or other regulatory processes. This review summarises the recent advances on the regulation and protein–protein interactions controlling the formation of sirohaem and haem b in bacteria.
Descrição
Funding Information: This work was financially supported by Fundação para a Ciência e Tecnologia (Portugal) by grant PTDC/BIA-BQM/28642/2017 and through R&D unit LISBOA-01-0145-FEDER007660 (MostMicro) cofounded by FCT/MCTES and FEDER funds under the PT2020 Partnership Agreement. We also acknowledge funding from the European Union's Horizon 2020 research and innovation programme under grant agreement No. 810856. JB is recipient of the MSCA-IF-2019 Individual Fellowship H2020-WF-02-2019, 101003441. Funding Information: This work was financially supported by Fundação para a Ciência e Tecnologia (Portugal) by grant PTDC/BIA-BQM/28642/2017 and through R&D unit LISBOA-01-0145-FEDER007660 (MostMicro) cofounded by FCT/MCTES and FEDER funds under the PT2020 Partnership Agreement. We also acknowledge funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No. 810856. JB is recipient of the MSCA-IF-2019 Individual Fellowship H2020-WF-02-2019, 101003441. Publisher Copyright: © 2021 Elsevier B.V.
Palavras-chave
Haem biosynthesis Protein–protein interactions Regulation Sirohaem Physical and Theoretical Chemistry Inorganic Chemistry Materials Chemistry