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Deciphering molecular mechanisms of downstream steps in Base Excision Repair (BER)
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Resumo(s)
Deinococcus radiodurans is a remarkable bacterium known for its extreme desiccation and radiation resistance. The mechanisms behind its extreme resistance are not well understood. However, an efficient DNA repair system, which includes Base Excision Repair (BER), is an important part of these mechanisms. BER repairs endogenous and exogenous damaged bases, abasic sites and strand breaks in DNA. To gain insights into the downstream mechanisms of BER and its potential impact on the extremophilic properties of D. radiodurans, we investigated the role of two key enzymes in this pathway, DNA polymerase I (DrPoll) and DNA ligase A (DrLigA).
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BER molecular mechanism