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Dissecting intra-tumor clonal dynamics and its crosstalk with the microenvironment in a zebrafish xenograft model
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Colorectal cancer represents one of the major leading causes for cancer-related death worldwide. Despite several efforts to improve cancer patient survival, recurrence and disease progression rates remain unacceptably high.
The current colorectal cancer (CRC) classification, prognosis prediction and therapeutic decision-making are based on histopathological features – the tumor, lymph node, metastasis (TNM) staging. Therefore, patients are treated using a one-size-fits all strategy based on tumor stage and some predictive indications
(prognostic molecular markers) of therapeutic response. The major hurdle of this approach is that it fails to identify and predict which patients will benefit from treatment and which will not. As a result, some patients benefit from treatment while others are inadequately treated, or overtreated with chemotherapeutics that come with substantial side effects.
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Colorectal cancer cancer treatment