Influenza A virus Inclusions are Liquid Condensates that can be Pharmacologically Hardened

Etibor, Temitope Akhigbe

http://hdl.handle.net/10362/152700

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Autores

Etibor, Temitope Akhigbe

Orientador(es)

Amorim, Maria João

Resumo(s)

Influenza A virus (IAV) is relevant to human and veterinary health as it causes seasonal epidemic and sporadic pandemics with excess mortality (Hampson and Mackenzie, 2006; Martin-Benito and Ortin, 2013; Vale-Costa et al., 2016a; Silvia Vale-Costa and Amorim, 2016). A way to reduce the risks of IAV disease is the yearly vaccination programmes, which has a reported 40-60% efficiency, pointing to the need for a more efficacious solution. This is only possible by gaining thorough understanding of IAV biology at the fundamental level, which could then inform the development of new antiviral therapeutics.