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Publicação
THE ROLE OF VISUAL EXPERIENCE IN THE ORGANIZATION OF CORTICO CORTICAL FEEDBACK
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Orientador(es)
Resumo(s)
Cortical feedback (FB) projections are thought to modulate lower order activity depending on learned expectations. However, whether FB inputs become bound to specific lower-order neurons depending on
experience is unknown. We measured the effects of dark rearing and manipulations of experienced visual statistics on the retinotopic specificity of projections from the lateromedial (LM) visual area to layer 1 of the
mouse primary visual cortex (V1). LM inputs were, on average, retinotopically matched with V1 neurons irrespective of visual experience. While the orientation tuning of LM axons determined the retinotopic
position of the V1 neurons they innervated, this organization was absent in dark-reared mice. Restricting visual experience to a narrow range of orientations revealed that visual experience exerts an instructive role in the
retinotopic organization of LM inputs in V1. Our observations support theories of hierarchical computation proposing that inputs from higher order neurons to lower-order ones reflect learned hierarchical associations
and that FB possibly plays role in contextual modulation mechanisms by learning statistical regularities of the world.
Descrição
Palavras-chave
cortical feedback mouse visual cortex