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The extracellular matrix dimension of skeletal muscle development
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Orientador(es)
Resumo(s)
Cells anchor to substrates by binding to extracellular matrix (ECM). In addition to this anchoring function however, cell-ECM binding is a mechanism for cells to sense their surroundings and to communicate and coordinate behaviour amongst themselves. Several ECM molecules and their receptors play essential roles in muscle development and maintenance. Defects in these proteins are responsible for some of the most severe muscle dystrophies at every stage of life from neonates to adults. However, recent studies have also revealed a role of cell-ECM interactions at much earlier stages of development as skeletal muscle forms. Here we review which ECM molecules are present during the early phases of myogenesis, how myogenic cells interact with the ECM that surrounds them and the potential consequences of those interactions. We conclude that cell-ECM interactions play significant roles during all stages of skeletal muscle development in the embryo and suggest that this "extracellular matrix dimension" should be added to our conceptual network of factors contributing to skeletal myogenesis.
Descrição
Funding Information: We thank Christine L. Mummery for critically reading the manuscript and Harold Erickson for giving the anti-tenascin antibody ( Fig. 3 F,G). This review is an output of Fundação para a Ciência e a Tecnologia (FCT, Portugal) contracts POCTI/BCI/47681/2002 and PTDC/BIA-BCM/67437/2006 and benefitted from work done within the Network of Excellence “Cells into Organs” (FP6/EU). M.D. and A.S.C. are supported by FCT post-doc fellowships ( SFRH/BPD/65370/2009 and SFRH/BPD/42056/2007 ) and F.B. has a Marie Curie Intra-European Fellowship for Career Development (IEF).
Palavras-chave
Adhesion Embryo Extracellular matrix Integrins Morphogenesis Myogenesis Skeletal muscle development Somite Molecular Biology Developmental Biology Cell Biology