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Publicação
Integrated continuos manufaturing of adeno-associated virus
| Nome: | Descrição: | Tamanho: | Formato: | |
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| 5.28 MB | Adobe PDF |
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Resumo(s)
"Adeno-associated viruses (AAV) constitute one of the most explored vectors in gene therapy for their safety, long-term expression, ability to transduce differentiated cells, and tropism. Depending on the disease targeted, AAV- based therapies can be associated with high vector demands impelling the development of processing strategies to supply the required doses. The main challenges reported include low titers generated, the quality of the product, high process volumes, equipment footprint, and the time frames associated with producing such high vector quantities.(...)"
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Palavras-chave
Adeno-associated viruses purification