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Publicação
Injectable hydrogels based on pluronic/water systems filled with alginate microparticles for biomedical applications
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Orientador(es)
Resumo(s)
A (model) composite system for drug delivery was developed based on a thermoresponsive hydrogel loaded with microparticles. We used Pluronic F127 hydrogel as the continuous phase and alginate microparticles as the dispersed phase of this composite system. It is well known that Pluronic F127 forms a gel when added to water in an appropriate concentration and in a certain temperature range. Pluronic F127 hydrogel may be loaded with drug and injected, in its sol state, to act as a drug delivery system in physiological environment. A rheological characterization allowed the most appropriate concentration of Pluronic F127 (15.5 wt%) and appropriate alginate microparticles contents (5 and 10 wt%) to be determined. Methylene blue (MB) was used as model drug to perform drug release studies in MB loaded Pluronic hydrogel and in MB loaded alginate microparticles/Pluronic hydrogel composite system. The latter showed a significantly slower MB release than the former (10 times), suggesting its potential in the development of dual cargo release systems either for drug delivery or tissue engineering.
Descrição
The financial support received from the Portuguese Foundation for Science and Technology through the strategic project 288 UID/CTM/50025/2019 (Cenimat/I3N) and from the Spanish Ministerio de Economia y Competitividad as well as from V Plan Propio Universidad de Sevilla, and the European Commission (FEDER Programme) is kindly acknowledged.
Palavras-chave
Alginate microparticles Composites Dual cargo delivery systems Injectable gels Pluronic/water systems Rheology General Materials Science