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Publicação
earlyMYCO
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Orientador(es)
Resumo(s)
Early-life exposure occurs during gestation through transfer to the fetus and later, during lactation. Recent monitoring data revealed that the Portuguese population is exposed to mycotoxins, including young children. This study aimed to develop a pilot study to assess the earlylife exposure to mycotoxins through a mother–child cohort, and to identify the associated challenges. Participants were recruited during pregnancy (1st trimester) and followed-up in three moments of observation: 2nd trimester of pregnancy (mother), and 1st and 6th month of the child’s life (mother and child), with the collection of biological samples and sociodemographic and food consumption data. The earlyMYCO pilot study enrolled 19 mother–child pairs. The analysis of biological samples from participants revealed the presence of 4 out of 15 and 5 out of 18 mycotoxins’ biomarkers of exposure in urine and breast milk samples, respectively. The main aspects identified as contributors for the successful development of the cohort were the multidisciplinary and dedicated team members in healthcare units, reduced burden of participation, and the availability of healthcare units for the implementation of the fieldwork. Challenges faced, lessons learned, and suggestions were discussed as a contribution for the development of further studies in this area.
Descrição
Funding Information: Funding: The earlyMYCO study was funded by Foundation for Science and Technology (PTDC/DTP-MEDTOX/28762/2017), by CESAM (UIDP/50017/2020+UIDB/50017/2020) and by the project MYTOX-SOUTH, Ghent University Global Minds programme. The funding sources were not involved in study design, in the collection, analysis and interpretation of data, and in the decision to submit the article for publication. Publisher Copyright: © 2022 by the authors. Licensee MDPI, Basel, Switzerland.
Palavras-chave
birth cohorts early-life exposure exposome mycotoxins Portugal Pollution Public Health, Environmental and Occupational Health Health, Toxicology and Mutagenesis SDG 3 - Good Health and Well-being