Advancing liver stage malaria in vitro models for drug discovery

Abstract

"The malaria drug pipeline has been highly affected by the fastdeveloping rate of Plasmodium resistance to the currently available drugs. There are two promising and complementary approaches being explored to mitigate drug resistance. One is focused on the drugs, and includes the development of drugs exploiting novel targets and the combination of drug partners presenting the same pharmacokinetic properties but distinct modes of action. The other approach is to explore the life cycle of the parasite and target the hepatic stage of the Plasmodium life cycle.(...)"