Regularization techniques in radiomics

Carrasquinha, Eunice; Santinha, João; Mongolin, Alexander; Lisitskiya, Maria; Ribeiro, Joana; Cardoso, Fátima; Matos, Celso; Vanneschi, Leonardo; Papanikolaou, Nickolas

http://hdl.handle.net/10362/142032

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Autores

Papanikolaou, Nickolas

Resumo(s)

Clinicians have shown an increasing interest in quantitative imaging for precision medicine. Imaging features can extract distinct phenotypic differences of tumours, potentially they can be used as a non-invasive prognostic tool and contribute for a better prediction of pathological Complete Response (pCR). However, the high-dimensional nature of the data brings many constraints, for which several approaches have been considered, with regularization techniques in the cutting-edge research front. In this work, classic lasso, ridge and the recently proposed priority-lasso are applied to high-dimensional imaging data, regarding a binary outcome. A breast cancer dataset, with radiomics, clinical and pathological information as features, was used. The application of sparsity techniques to the dataset enabled the selection of relevant features extracted in MRI of breast cancer patients, in order to identify the accuracy of those features and predict the pCR in the breast and the axilla.

Descrição

Carrasquinha, E., Santinha, J., Mongolin, A., Lisitskiya, M., Ribeiro, J., Cardoso, F., Matos, C., Vanneschi, L., & Papanikolaou, N. (2020). Regularization techniques in radiomics: A case study on the prediction of pCR in breast tumours and the axilla. In P. Cazzaniga, D. Besozzi, I. Merelli, & L. Manzoni (Eds.), Computational Intelligence Methods for Bioinformatics and Biostatistics: 16th International Meeting, CIBB 2019, Revised Selected Papers (pp. 271-281). (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); Vol. 12313 LNBI). Springer Science and Business Media Deutschland GmbH. https://doi.org/10.1007/978-3-030-63061-4_24

Palavras-chave

Breast cancer High-dimensional data Radiomic features Regularization techniques Theoretical Computer Science General Computer Science SDG 3 - Good Health and Well-being