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Proteomics based approach to understand tissue regeneration
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Resumo(s)
Most echinoderm species share an outstanding capacity for regeneration that is maintained throughout
the adult animal lifespan. Regeneration allows these deuterostomes to recover from predation injuries or selfinduced
arm autotomy, which are known to occur frequently in nature. Although echinoderms are extremely
interesting in terms of their phylogenetic proximity to chordates, most areas of echinoderm research have been
neglected in recent years. These wonderful animals quickly shifted from being the preferred animal models in the
19th-20th centuries of the pioneer regenerationists to scientific oblivion. Other species, for which the possibility of
conducting genetic studies became available, are now favored. After the sequencing of an echinoderm species
genome, the sea urchin Strongylocentrotus purpuratus in 2006, several scientific reports of interesting molecular
studies were published.(...)
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Dissertation presented to obtain the PhD degree in Biochemistry
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Universidade Nova de Lisboa. Instituto de Tecnologia Química e Biológica