Utilize este identificador para referenciar este registo: http://hdl.handle.net/10362/14116
Título: PROTEIN FOLDING AND DISEASE THE MITOCHONDRIAL PROTEIN FRATAXIN
Autor: Correia, Ana Raquel Viegas
Orientador: Gomes, Cláudio
Data de Defesa: Fev-2010
Resumo: This dissertation focuses on the study of frataxin, a small mitochondrial protein whose deficiency is associated with the neurodegenerative disease Friedreich's ataxia (FRDA). Aiming at a better understanding of frataxin conformational and functional properties, two lines of research were followed: first, the effect of FRDA-related mutations in human frataxin (FXN) were studied and the role of oxidative stress related modification addressed; second, yeast frataxin (Yfh1) orthologue was used to explore the conformational and functional properties of the protein.(...)
URI: http://hdl.handle.net/10362/14116
Designação: Dissertation presented to obtain the PhD degree in Biochemistry
Aparece nas colecções:ITQB: PBFS - PhD Theses

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