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Synchronization properties of multi-oscillator circadian systems
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Circadian oscillators are usually regarded as time-keeping mechanisms
that can synchronize to environmental cycles (zeitgebers) and coordinate
the timing of virtually all aspects of organismal function. Circadian pacemakers
would be the main time-keepers that synchronize to light/dark
cycles and convey temporal information to peripheral oscillators. However,
the idea of circadian systems as being simple clocks is challenged
by the coexistence, within the same organism, of multiple circadian oscillators
with diverse synchronization strategies.(...)
Descrição
Dissertation presented to obtain the Ph.D degree in Computational Biology
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Universidade Nova de Lisboa. Instituto de Tecnologia Química e Biológica.