Molecular Recognition by Pillar[5]arenes Evidence for Simultaneous Electrostatic and Hydrophobic Interactions

Utilize este identificador para referenciar este registo: http://hdl.handle.net/10362/134249

Título:	Molecular Recognition by Pillar[5]arenes Evidence for Simultaneous Electrostatic and Hydrophobic Interactions
Autor:	Gómez-González, Borja García-Río, Luis Basílio, Nuno Mejuto, Juan C. Simal-Gandara, Jesus
Palavras-chave:	Host:guest Hydrophobic ITC NMR Pillararene Supramolecular Pharmaceutical Science
Data:	Jan-2022
Citação:	Gómez-González, B., García-Río, L., Basílio, N., Mejuto, J. C., & Simal-Gandara, J. (2022). Molecular Recognition by Pillar[5]arenes Evidence for Simultaneous Electrostatic and Hydrophobic Interactions. Pharmaceutics, 14(1), Article 60. https://doi.org/10.3390/pharmaceutics14010060
Resumo:	The formation of inclusion complexes between alkylsulfonate guests and a cationic pil-lar[5]arene receptor in water was investigated by NMR and ITC techniques. The results show the formation of host-guest complexes stabilized by electrostatic interactions and hydrophobic effects with binding constants of up to 107 M−1 for the guest with higher hydrophobic character. Structurally, the alkyl chain of the guest is included in the hydrophobic aromatic cavity of the macrocycle while the sulfonate groups are held in the multicationic portal by ionic interactions.
Descrição:	CTQ2017-84354-P (GR 2007/085ED431C2018/42-GRC)
Peer review:	yes
URI:	http://hdl.handle.net/10362/134249
DOI:	https://doi.org/10.3390/pharmaceutics14010060
ISSN:	1999-4923
Aparece nas colecções:	FCT: DQ - Artigos em revista internacional com arbitragem científica

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pharmaceutics_14_00060.pdf		2,97 MB	Adobe PDF	Ver/Abrir