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Effects of inorganic mercury exposure in the alveolar bone of rats: an approach of qualitative and morphological aspects

2022-01Artigo científico Acesso aberto
http://hdl.handle.net/10362/134189
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Autores

de Oliveira Nunes, Paula Beatriz
Ferreira, Maria Karolina Martins
Frazão, Deborah Ribeiro
Bittencourt, Leonardo Oliveira
dos Santos Chemelo, Victória
Silva, Márcia Cristina Freitas
Pereira-Neto, Armando Lopes
Albuquerque, Alan Rodrigo Leal
Paz, Simone Patricia Aranha
Angélica, Rômulo Simões

Orientador(es)

Resumo(s)

Background: In comparison to organic mercury (MeHg), the environmental inorganic mercury (IHg) can be found in some skin-lightening cosmestics were considered “harmless” for a long time. However, recent studies have shown that long-term exposure to low doses of IHg may affect biological systems. Therefore, this study investigated the effects of IHg long-term exposure to the alveolar bone of adult rats. Methods: Adult Wistar rats were distributed in control and HgCl2 exposed (0.375 mg/kg/day). After 45 days, the rats were euthanized and both blood and hemimandibles were collected. Total blood Hg levels were measured and both inorganic and organic components of the alveolar bone were determined through XRD and ATR-FTIR. The microstructure of the alveolar bone was assessed by using micro-CT and the morphometric analysis was performed by using stereomicroscopy. Results: Alterations in the physicochemical components of the alveolar bone of exposed animals were observed. The bone changes represented a tissue reaction at the microstructural level, such as bone volume increase. However, no significant dimensional changes (bone height) were observed. Conclusion: Exposure to IHg at this dose can promote microstructural changes and alteration in the organic and inorganic components in the alveolar bone.

Descrição

Pró-Reitoria de Pesquisa (PACI/PROPESP/UFPA/ Brazil), Brazilian National Council for Scientific and Technological Development (CNPq), Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - Brazil (CAPES) – Finance Cod 001

Palavras-chave

Alveolar bone Infrared mineral characterization Inorganic mercury Mercury chloride Micro-computed tomography Rats General Neuroscience General Biochemistry,Genetics and Molecular Biology General Agricultural and Biological Sciences

URI

http://hdl.handle.net/10362/134189

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Editora

DOI

10.7717/peerj.12573

Coleções

Home collection (FCT)

Licença CC

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