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The role of low-energy electron interactions in cis-pt(Co)2 br2 fragmentation
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Orientador(es)
Resumo(s)
Platinum coordination complexes have found wide applications as chemotherapeutic anticancer drugs in synchronous combination with radiation (chemoradiation) as well as precursors in focused electron beam induced deposition (FEBID) for nano-scale fabrication. In both applications, low-energy electrons (LEE) play an important role with regard to the fragmentation pathways. In the former case, the high-energy radiation applied creates an abundance of reactive photo-and secondary electrons that determine the reaction paths of the respective radiation sensitizers. In the latter case, low-energy secondary electrons determine the deposition chemistry. In this contribution, we present a combined experimental and theoretical study on the role of LEE interactions in the fragmentation of the Pt(II) coordination compound cis-PtBr2 (CO)2. We discuss our results in conjunction with the widely used cancer therapeutic Pt(II) coordination compound cis-Pt(NH3)2 Cl2 (cisplatin) and the carbonyl analog Pt(CO)2 Cl2, and we show that efficient CO loss through dissociative electron attachment dominates the reactivity of these carbonyl complexes with low-energy electrons, while halogen loss through DEA dominates the reactivity of cis-Pt(NH3)2 Cl2.
Descrição
no. 13049305(1−3)
CHE-1607547
CHE-1904802
Palavras-chave
Anticancer drugs Cisplatin Dissociative electron attachment Dissociative ionization Focused electron beam induced deposition Low-energy electrons Platinum (II) halo-carbonyl complexes Catalysis Molecular Biology Spectroscopy Computer Science Applications Physical and Theoretical Chemistry Organic Chemistry Inorganic Chemistry SDG 3 - Good Health and Well-being