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Resumo(s)
Research on vaccines against trypanosomatids, a family of protozoa that cause neglected tropical diseases, such as Chagas disease, leishmaniasis, and sleeping sickness, is a current need. Today, according to modern vaccinology, virus-like particle (VLP) technology is involved in many vaccines, including those undergoing studies related to COVID-19. The potential use of VLPs as vaccine adjuvants opens an opportunity for the use of protozoan antigens for the development of vaccines against diseases caused by Trypanosoma cruzi, Leishmania spp., and Trypanosoma brucei. In this context, it is important to consider the evasion mechanisms of these protozoa in the host and the antigens involved in the mechanisms of the parasite–host interaction. Thus, the immunostimulatory properties of VLPs can be part of an important strategy for the development and evaluation of new vaccines. This work aims to highlight the potential of VLPs as vaccine adjuvants for the development of immunity in complex diseases, specifically in the context of tropical diseases caused by trypanosomatids.
Descrição
Funding Information: This research was funded by Global Health and Tropical Medicine (Grant number IHMT UID/multi/04413/2013 and Grant number PTDC/CVT-CVT/28908/2017), Funda??o para Ci?ncia e Tecnologia (FCT), Portugal; Grant GIU18/172 Grupos de Investigaci?n de la UPV/EHU, and Grant from CSIC Programa I-COOP+2020 (ICOOPB20503), Spain.A.M.V.Q., J.W.d.F.O., and C.J.M. thanks to the financial support (PhD scholar-ships) provided by CNPq and CAPES, Brazil. M.S.S. thanks to CNPq for the Research Grant (Bolsa de Produtividade em Pesquisa). We are also grateful to Paulo Fanado and Laysa Ohanna for editing this manuscript. Publisher Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland.
Palavras-chave
African try-panosomiasis Chagas disease Leishmaniasis Trypanosomatids Vaccine Virus-like particles Immunology Pharmacology Drug Discovery Infectious Diseases Pharmacology (medical) SDG 3 - Good Health and Well-being SDG 17 - Partnerships for the Goals