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Publicação
Molecular and Metabolic Reprogramming
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| 1.19 MB | Adobe PDF |
Orientador(es)
Resumo(s)
Metastasis is a major hurdle to the efficient treatment of cancer, accounting for the great majority of cancer-related deaths. Although several studies have disclosed the detailed mechanisms underlying primary tumor formation, the emergence of metastatic disease remains poorly understood. This multistep process encompasses the dissemination of cancer cells to distant organs, followed by their adaptation to foreign microenvironments and establishment in secondary tumors. During the last decades, it was discovered that these events may be favored by particular metabolic patterns, which are dependent on reprogrammed signaling pathways in cancer cells while they acquire metastatic traits. In this review, we present current knowledge of molecular mechanisms that coordinate the crosstalk between metastatic signaling and cellular metabolism. The recent findings involving the contribution of crucial metabolic pathways involved in the bioenergetics and biosynthesis control in metastatic cells are summarized. Finally, we highlight new promising metabolism-based therapeutic strategies as a putative way of impairing metastasis.
Descrição
Funding: The research group was funded by IPOLFG EPE and by iNOVA4Health (UID/Multi/04462/2019) a program financially supported by Fundação para a Ciência e Tecnologia (FCT)/ Ministério da Educação e Ciência, through national funds. All the fellowships were funded by FCT: AH (SFRH/BD/148441/ 2019), FM (2020.04780.BD), CM (2020.06956.BD), FL-C (PD/ BD/128337/2017).
Palavras-chave
metabolic reprogramming metastasis metastatic cascade new therapies tumor microenvironment Oncology Cancer Research SDG 3 - Good Health and Well-being