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Publicação
Integrated functional genomics for improved manufacture of recombinant enveloped virus
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| 14.97 MB | Adobe PDF |
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Resumo(s)
Biopharmaceuticals derived from recombinant viruses comprise a plethora of
prophylactic and therapeutic products from vaccines to gene therapy vectors.
Retroviruses occupy an important segment of this market. Replication-defective
vectors have extensively been used as delivery vehicles in gene therapy protocols.
Retrovirus-like-particles have shown promising results in vaccinology as immunogen
display platforms. Replication-competent particles have efficiently been used as
oncolytic agents. (...)
Descrição
Dissertation presented to obtain the Ph.D degree in Engineering and Technology Sciences-Biotechnology
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Editora
Universidade Nova de Lisboa. Instituto de Tecnologia Química e Biológica.