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Variation in protein expression levels in cell populations
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Resumo(s)
A widespread observation is that of variation in the expression levels of a molecule when
analyzing a snapshot of single cells from a population. One possible explanation for this
variation is that there are asynchronous fluctuations throughout time in the expression level
of each cell, for example due to noise in gene expression. Another explanation is that there
are so-called stable variants, groups of cells that have a permanent bias for a limited range
of expression levels compared with the levels observed in a snapshot of the population.
In an extreme scenario, each cell of the population would be a single stable variant with
an expression level that is constant as a function of time, without any fluctuations. Stable
variants could occur if the population is genetically diverse, with each clone being associated
with a particular expression level.(...)
Descrição
Dissertation presented to obtain the Ph.D degree in Systems Biology
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Universidade Nova de Lisboa. Instituto de Tecnologia Química e Biológica.