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Novel insights into the action of antimicrobial agents against human pathogens
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Resumo(s)
Nowadays, the growing increase of antibiotic resistance represents a
global public health concern. Hence, it is crucial to understand the mode of
action of antimicrobial agents and to develop new strategies to control
bacterial infections. The work presented in this thesis contributes with new
insights into the mechanisms that underpin the action of antimicrobial agents
against pathogenic bacteria through: (i) the study of a putative nitroreductase
of Staphylococcus aureus and its involvement in nitrofurans activation; (ii)
elucidation of the mechanisms that sustain the antibacterial activity of the
recently discovered Carbon Monoxide‐Releasing Molecules (CO‐RMs); and (iii)
evaluation of the bactericidal effect of CO‐RMs on Helicobacter pylori.(...)
Descrição
Dissertation presented to obtain the Ph.D degree in Biochemistry
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Universidade Nova de Lisboa. Instituto de Tecnologia Química e Biológica.