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Uncovering the role of IFNAR1 in Experimental Cerebral malaria
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Cerebral malaria is a severe and fatal form of clinical Plasmodium
falciparum infection, resulting in brain injury from a damaging
cascade of vascular, inflammatory and immunological host
responses. However progression to cerebral malaria can be
modified by host genetic factors. This thesis work extensively
reveals the role of Interferon type I receptor (IFNAR1) in the
development of Experimental cerebral malaria, through the use of
the mouse model Ifnar1-/-. We found Ifnar1-/- mice protected from
Experimental cerebral malaria upon infection with Plasmodium
berghei ANKA-GFP, compared with susceptible wild-type C57BL/6
mice. Ifnar1-/- mice showed diminished blood brain barrier breakage,
despite parasite accumulation in the periphery and accumulation of
immune cells within the brain tissue during infection.(...)
Descrição
Dissertation presented the Ph.D degree in Biology
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Universidade Nova de Lisboa. Instituto de Tecnologia Química e Biológica.