A carregar...
Publicação
All-in-one microfluidic assembly of insulin-loaded pH-responsive nano-in-microparticles for oral insulin delivery
| Nome: | Descrição: | Tamanho: | Formato: | |
|---|---|---|---|---|
| 2.08 MB | Adobe PDF |
Orientador(es)
Resumo(s)
Here, a continuous two-step glass-capillary microfluidic technique to produce a multistage oral delivery system is reported. Insulin is successfully encapsulated into liposomes, which are coated with chitosan to improve their mucoadhesion. The encapsulation in an enteric polymer offers protection from the harsh gastric conditions. Insulin permeability is enhanced across an intestinal monolayer.
Descrição
UIDB/50006/2020 PD/BD/142880/2018 UID/DTP/04138/2020
Palavras-chave
Biomedical Engineering General Materials Science