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Robust tolerance out of volatile Regulatory T cells
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"Natural tolerance is the ability of the immune system to prevent any immune re- sponse against body components and tissues. This capacity coexists with and cannot be disentangled by the ability of the immune system to recognize and fight against any kind of fast evolving pathogen that enters the body. The pro- cess of natural tolerance is so robust and inconspicuous in healthy individuals that it shows its actual immunological nature when it fails, in pathologic condi- tions referred as autoimmune diseases. Autoimmunity consists in the disruption of body tissues orchestrated by the immune system cells. Namely during au- toimmunity, the immune system uses against its own tissues and organs the very same destructive mechanisms otherwise used for fighting pathogens. It occurs together with an uncontrolled clonal expansion of auto-reactive lymphocytes.(...)"
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Tolerance Robust Immune System