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Induced-Fit Recognition by a Calixarene–Pyrene Conjugate for Single- and Dual-Wavelength Fluorescence Sensing in Water

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dc.contributor.authorMartins, Joana N.
dc.contributor.authorPessêgo, Márcia
dc.contributor.authorGarcia-Rio, Luis
dc.contributor.authorLima, João Carlos
dc.contributor.authorBasílio, Nuno
dc.contributor.institutionDQ - Departamento de Química
dc.contributor.institutionLAQV@REQUIMTE
dc.contributor.pblWiley
dc.date.accessioned2026-07-07T07:41:02Z
dc.date.available2026-07-07T07:41:02Z
dc.date.issued2026
dc.descriptionThis work was financed by national funds from FCT—Fundaçãopara a Ciência e a Tecnologia, I.P., under the scope of the projectUID/50006/2023 of the Associate Laboratory for Green Chemistry- LAQVREQUIMTE. FCT is also acknowledged for supporting the National Portuguese NMR Network (ROTEIRO/0031/2013-PINFRA/22161/2016,cofinanced by FEDER through COMPETE 2020, POCI, PORL, andFCT through PIDDAC). Publisher Copyright: © 2026 The Author(s). Chemistry – A European Journal published by Wiley-VCH GmbH.
dc.description.abstractThe discovery of fluorescence receptors that selectively bind small molecules with high affinity in aqueous media is critical for the development of new sensing and bioimaging assays. We herein report a new fluorescence receptor-dye chemosensor based on the monofunctionalization of p-sulfonatocalix[4]arene (SC4) receptor with pyrene (SC4-4Py). The SC4-4Py conjugate was found to retain the exceptional binding properties of SC4, allowing the high-affinity recognition of neurotransmitters, amino acids, and biogenic amines in aqueous solution and their optical detection. The SC4-4Py chemosensor operates through a photoinduced electron transfer (PET) mechanism triggered by conformational changes in the calixarene structure upon binding, allowing single-wavelength fluorescence detection of target analytes and its expansion into a dual-wavelength ratiometric indicator displacement assay (IDA) that relies on competitive PET between the pyrene and non-covalently bound lucigenin dye.en
dc.description.versionpublishersversion
dc.description.versioninpress
dc.format.extent2048894
dc.identifier.doi10.1002/chem.202503407
dc.identifier.issn0947-6539
dc.identifier.otherPURE: 151351836
dc.identifier.otherPURE UUID: 04dc3fb2-124c-40c9-a6d7-932c27a1eabf
dc.identifier.otherScopus: 105027691858
dc.identifier.urihttp://hdl.handle.net/10362/204365
dc.identifier.urlhttps://www.scopus.com/pages/publications/105027691858
dc.language.isoeng
dc.peerreviewedyes
dc.relationinfo:eu-repo/grantAgreement/FCT/Concurso de Projetos de I&D em Todos os Domínios Científicos - 2022/2022.02538.PTDC/PT
dc.relationinfo:eu-repo/grantAgreement/FCT//2021.06296.BD/PT
dc.subjectcalixarenes
dc.subjectchemosensors
dc.subjecthost-guest systems
dc.subjectinduced-fit recognition
dc.subjectratiometric probes
dc.subjectCatalysis
dc.subjectGeneral Chemistry
dc.subjectOrganic Chemistry
dc.titleInduced-Fit Recognition by a Calixarene–Pyrene Conjugate for Single- and Dual-Wavelength Fluorescence Sensing in Wateren
dc.typejournal article
degois.publication.titleChemistry - A European Journal
dspace.entity.typePublication
rcaap.rightsopenAccess

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