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Paricalcitol and Extended-Release Calcifediol for Treatment of Secondary Hyperparathyroidism in Non-Dialysis Chronic Kidney Disease

2023-10-18Artigo científico Acesso aberto
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dc.contributor.authorFranchi, Matteo
dc.contributor.authorFRANCHI, MATTEO
dc.contributor.authorGunnarsson, Joel
dc.contributor.authorGunnarsson, Joel
dc.contributor.authorGonzales-Parra, Emilio
dc.contributor.authorFerreira, Anibal
dc.contributor.authorStröm, Oskar
dc.contributor.authorCorrao, Giovanni
dc.contributor.authorCORRAO, GIOVANNI
dc.contributor.institutionNOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
dc.contributor.pblEndocrine Society
dc.date.accessioned2023-11-16T22:09:48Z
dc.date.available2023-11-16T22:09:48Z
dc.date.issued2023-10-18
dc.description.abstractCONTEXT: Secondary hyperparathyroidism (SHPT) is a complication of chronic kidney disease (CKD) affecting mineral and bone metabolism and characterized by excessive parathyroid hormone (PTH) production and parathyroid hyperplasia. OBJECTIVE: The objective of this analysis was to compare the efficacy and adverse effects of extended-release calcifediol (ERC) and paricalcitol (PCT) by assessing their effect on the biomarkers PTH, calcium, and phosphate in patients with non-dialysis CKD (ND-CKD). METHODS: A systematic literature research was performed in PubMed to identify randomized control trials (RCTs). Quality assessment was done with the GRADE method. The effects of ERC vs PCT were compared using random effects in a frequentist setting. RESULTS: Nine RCTs comprising 1426 patients were included in the analyses. The analyses were performed on 2 overlapping networks, due to nonreporting of outcomes in some of the included studies. No head-to-head trials were identified. No statistically significant differences in PTH reduction were found between PCT and ERC. Treatment with PCT showed statistically significant increases in calcium compared with ERC (0.2 mg/dL increase; 95% CI, -0.37 to -0.05 mg/dL). No differences in effects on phosphate were observed. CONCLUSION: This network meta-analysis showed that ERC is comparable in lowering PTH levels vs PCT. ERC displayed avoidance of potentially clinically relevant increases in serum calcium, offering an effective and well-tolerated treatment option for the management of SHPT in patients with ND-CKD.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent493130
dc.identifier.doi10.1210/clinem/dgad289
dc.identifier.issn0021-972X
dc.identifier.otherPURE: 75003074
dc.identifier.otherPURE UUID: 2688dad6-80d8-4e4a-a7be-3f9a4069a8d6
dc.identifier.otherScopus: 85174642299
dc.identifier.otherPubMed: 37235771
dc.identifier.urihttp://hdl.handle.net/10362/160049
dc.identifier.urlhttps://www.scopus.com/pages/publications/85174642299
dc.language.isoeng
dc.peerreviewedyes
dc.subjectbone/mineral metabolism
dc.subjecthypercalcemia
dc.subjecthyperparathyroidism
dc.subjectmetabolic bone disease
dc.subjectvitamin D
dc.subjectEndocrinology, Diabetes and Metabolism
dc.subjectBiochemistry
dc.subjectEndocrinology
dc.subjectClinical Biochemistry
dc.subjectBiochemistry, medical
dc.subjectSDG 3 - Good Health and Well-being
dc.titleParicalcitol and Extended-Release Calcifediol for Treatment of Secondary Hyperparathyroidism in Non-Dialysis Chronic Kidney Diseaseen
dc.title.subtitleResults From a Network Meta-Analysisen
dc.typejournal article
degois.publication.firstPagee1424
degois.publication.issue11
degois.publication.lastPagee1432
degois.publication.titleThe Journal of clinical endocrinology and metabolism
degois.publication.volume108
dspace.entity.typePublication
person.familyNameFRANCHI
person.familyNameGunnarsson
person.familyNameCORRAO
person.givenNameMATTEO
person.givenNameJoel
person.givenNameGIOVANNI
person.identifier1943027
person.identifier.orcid0000-0001-9620-8057
person.identifier.orcid0000-0002-2903-1682
person.identifier.orcid0000-0002-1034-8444
rcaap.rightsopenAccess
relation.isAuthorOfPublication20f7e25f-1a3a-4de0-9796-bf0d453ef502
relation.isAuthorOfPublication5c27a630-be98-4472-ae4d-424fd7dfaa33
relation.isAuthorOfPublication9b40f84e-4de8-4a2b-adce-a3d6d13c96fe
relation.isAuthorOfPublication.latestForDiscovery20f7e25f-1a3a-4de0-9796-bf0d453ef502

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