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The Efficacy of Transcranial Magnetic Stimulation in the Treatment of ObsessiveCompulsive Disorder

2024-04-06Recensão Acesso aberto
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dc.contributor.authorKar, SK
dc.contributor.authorAgrawal, A
dc.contributor.authorSilva-dos-Santos, A
dc.contributor.authorGupta, Y
dc.contributor.authorDeng, ZD
dc.contributor.institutionNOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
dc.contributor.pblCambridge University Press
dc.date.accessioned2024-05-01T00:12:12Z
dc.date.available2024-05-01T00:12:12Z
dc.date.issued2024-04-06
dc.description.abstractBackground. Repetitive transcranial magnetic stimulation (rTMS) has been increasingly used for treating obsessive-compulsive disorder (OCD). Although several meta-analyses have explored its effectiveness and safety, there is no umbrella review specifically focused on rTMS for OCD. This umbrella review followed Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines and analyzed relevant meta-analyses on rTMS for OCD. Methods. Twenty-three articles were identified from PubMed, and after screening, 12 meta-analyses were included in the review. The studies analyzed in the meta-analyses ranged from 10 to 27, with total participants ranging from 282 to 791. The most commonly studied regions were the dorsolateral prefrontal cortex (DLPFC), supplementary motor area (SMA), and orbitofrontal cortex (OFC). Result. The majority of the meta-analyses consistently supported the effectiveness of rTMS in reducing OCD symptoms when applied to the DLPFC and SMA. Encouraging results were also observed when targeting the medial prefrontal cortex (mPFC) and anterior cingulate cortex (ACC) through deep transcranial magnetic stimulation (dTMS). However, there was a high level of heterogeneity in the findings of nine out of 12 meta-analyses. Conclusion. In conclusion, existing evidence suggests that rTMS targeting the DLPFC and SMA consistently reduces OCD symptoms, but targeting the mPFC and ACC through dTMS shows variable results. However, the high heterogeneity in the study findings indicates a need for further research and standardization in the field.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent402707
dc.identifier.doi10.1017/S1092852923006387
dc.identifier.issn1092-8529
dc.identifier.otherPURE: 81032540
dc.identifier.otherPURE UUID: e3ef0632-cc94-4798-bb52-10179a3d03c9
dc.identifier.otherWOS: 001129479000001
dc.identifier.otherPubMed: 38053347
dc.identifier.otherScopus: 85179494370
dc.identifier.urihttp://hdl.handle.net/10362/166830
dc.identifier.urlhttps://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=nova_api&SrcAuth=WosAPI&KeyUT=WOS:001129479000001&DestLinkType=FullRecord&DestApp=WOS
dc.language.isoeng
dc.peerreviewedyes
dc.subjectTranscranial magnetic stimulation
dc.subjectEfficacy
dc.subjectEvidence
dc.subjectMeta-analysis
dc.subjectObsessive-compulsive disorder
dc.titleThe Efficacy of Transcranial Magnetic Stimulation in the Treatment of ObsessiveCompulsive Disorderen
dc.title.subtitleAn Umbrella Review of Meta-Analysesen
dc.typereview
degois.publication.firstPage109
degois.publication.issue2
degois.publication.lastPage118
degois.publication.titleCNS Spectrums
degois.publication.volume29
dspace.entity.typePublication
rcaap.rightsopenAccess

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