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Application of General Unified Threshold Models to Predict Time-Varying Survival of Mayfly Nymphs Exposed to Three Neonicotinoids

2024-04-10Artigo científico Acesso aberto
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dc.contributor.authorLourenço, Vanessa S. C.
dc.contributor.authorFigueiredo, Neusa L.
dc.contributor.authorDaam, Michiel A.
dc.contributor.institutionCENSE - Centro de Investigação em Ambiente e Sustentabilidade
dc.contributor.institutionMARE - Centro de Ciências do Mar e do Ambiente
dc.contributor.pblMDPI - Multidisciplinary Digital Publishing Institute
dc.date.accessioned2024-09-20T22:21:27Z
dc.date.available2024-09-20T22:21:27Z
dc.date.issued2024-04-10
dc.descriptionPublisher Copyright: © 2024 by the authors.
dc.description.abstractPesticide exposure patterns tested in laboratory bioassays often do not match real-world pesticide exposure profiles in edge-of-field waterbodies. Toxicokinetic–toxicodynamic (TKTD) models are therefore increasingly used, as they allow for predictions of the toxic effects under actual time-variable field exposures. The TKTD models from the General Unified Threshold models of Survival (GUTS), for example, are considered ready for use by regulators for calculating the survival rates for any time-variable exposure profile. However, questions remain regarding their predictive power for compounds showing increased toxicity over time, such as neonicotinoid insecticides. The aim of the present study was therefore to compare the GUTS-predicted 28 d toxicity values of three neonicotinoids (imidacloprid, clothianidin, and thiamethoxam) for the common New Zealand mayfly genus Deleatidium spp. with those observed in a previously published study. Overall, the GUTS modeling results underestimated the toxicity values derived experimentally. From the three neonicotinoids, clothianidin showed the best fit between the estimated and observed 28 d LC50 (median-lethal-concentration) values. Shortcomings of the modeling exercise, future research needs, and implications for the application of GUTS models in regulatory risk assessment are discussed.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent14
dc.format.extent4938264
dc.identifier.doi10.3390/w16081082
dc.identifier.issn2073-4441
dc.identifier.otherPURE: 99760532
dc.identifier.otherPURE UUID: 62970ea0-191f-4d93-b885-518d75803fc2
dc.identifier.otherScopus: 85191530887
dc.identifier.otherWOS: 001220472900001
dc.identifier.otherORCID: /0000-0001-9203-5400/work/167956825
dc.identifier.urihttp://hdl.handle.net/10362/172155
dc.identifier.urlhttps://www.scopus.com/pages/publications/85191530887
dc.language.isoeng
dc.peerreviewedyes
dc.relationFunding Information: info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04085%2F2020/PT
dc.relationinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/LA%2FP%2F0121%2F2020/PT
dc.relationCHANGE - Global Change and Sustainability Institute
dc.relationMarine and Environmental Sciences Centre
dc.relationinfo:eu-repo/grantAgreement/FCT/Concurso para Atribuição do Estatuto e Financiamento de Laboratórios Associados (LA)/LA%2FP%2F0069%2F2020/PT
dc.subjectaquatic ecotoxicology
dc.subjectmacroinvertebrates
dc.subjectmayflies
dc.subjectneonicotinoid insecticides
dc.subjecttime-variable exposure
dc.subjecttoxicokinetic–toxicodynamic modeling
dc.subjectBiochemistry
dc.subjectGeography, Planning and Development
dc.subjectAquatic Science
dc.subjectWater Science and Technology
dc.titleApplication of General Unified Threshold Models to Predict Time-Varying Survival of Mayfly Nymphs Exposed to Three Neonicotinoidsen
dc.typejournal article
degois.publication.issue8
degois.publication.titleWater (Switzerland)
degois.publication.volume16
dspace.entity.typePublication
oaire.awardNumberLA/P/0121/2020
oaire.awardNumberUIDB/04292/2020
oaire.awardNumberLA/P/0069/2020
oaire.awardTitleCHANGE - Global Change and Sustainability Institute
oaire.awardTitleMarine and Environmental Sciences Centre
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/LA%2FP%2F0121%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04292%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/Concurso para Atribuição do Estatuto e Financiamento de Laboratórios Associados (LA)/LA%2FP%2F0069%2F2020/PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStreamConcurso para Atribuição do Estatuto e Financiamento de Laboratórios Associados (LA)
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccess
relation.isProjectOfPublication2c95e6bb-54af-4359-bf9d-e04f922f9e8b
relation.isProjectOfPublication891b698b-bed2-415d-82f8-0ebba38b40b3
relation.isProjectOfPublication9784d13b-ccc2-4c7f-8635-167d745ac0a7
relation.isProjectOfPublication.latestForDiscovery2c95e6bb-54af-4359-bf9d-e04f922f9e8b

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