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The Association of Aquaporins with MAPK Signaling Pathway Unveils Potential Prognostic Biomarkers for Pancreatic Cancer

2025-04Artigo científico Acesso aberto
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dc.contributor.authorda Silva, Inês V.
dc.contributor.authorVieira da Silva, Inês
dc.contributor.authorLopes, Paula A.
dc.contributor.authorAlexandra Lopes, Paula
dc.contributor.authorFonseca, Elisabete
dc.contributor.authorVigia, Emanuel
dc.contributor.authorVigia, Emanuel
dc.contributor.authorPaulino, Jorge
dc.contributor.authorPaulino, Jorge
dc.contributor.authorSoveral, Graça
dc.contributor.authorSoveral, Graça
dc.contributor.institutionNOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
dc.contributor.pblMDPI - Multidisciplinary Digital Publishing Institute
dc.date.accessioned2025-05-16T21:38:49Z
dc.date.available2025-05-16T21:38:49Z
dc.date.issued2025-04
dc.descriptionFunding Information: This research was funded by Funda\u00E7\u00E3o para a Ci\u00EAncia e Tecnologia (FCT), Portugal, grant 2022.06601.PTDC, researcher contracts 2022.03691.CEECIND to I.V.d.S. and DL57/2016 to P.A.L., and strategic project UID 04138\u2014Instituto de Investiga\u00E7\u00E3o do Medicamento (iMed.ULisboa). Publisher Copyright: © 2025 by the authors.
dc.description.abstractPancreatic cancer is one of the most lethal and challenging malignancies. Its severity is primarily linked to the constitutively activated mitogen-activated protein kinase (MAPK)/extracellular signal-regulated kinase (ERK) pathway. Aquaporins (AQPs) are frequently overexpressed in pancreatic cancer, playing crucial roles in cell signaling, and consequently promoting cell migration, proliferation, and invasion. Here, we investigate the transcriptomics of key players in epithelial–mesenchymal transition (EMT) and the MAPK/ERK signaling pathway in pancreatic cancer tissues, correlating them with tumor AQP expression to highlight their potential as diagnostic or prognostic tools. The transcriptomics analysis was conducted in 24 paired pancreatic tumors and adjacent healthy tissues, and analyses were performed considering the patients’ age and gender, as well as tumor invasiveness and aggressiveness. Our results revealed strong positive Pearson correlation coefficients between AQP3 and c-Jun, and between AQP5 and CDH1/EGFR in pancreatic tumors but not in healthy tissues, with posterior in vitro confirmation in pancreatic cancer BxPC3 cells, suggesting a shift in the regulatory mechanisms of gene expression that certainly affect the physiology of the tissue, influencing cancer initiation and progression. This study underscores the interplay between AQPs and cancer signaling pathways, opening new avenues for defining novel clinical biomarkers and improving the early detection of pancreatic cancer.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent1935721
dc.identifier.doi10.3390/biom15040488
dc.identifier.issn2218-273X
dc.identifier.otherPURE: 116055962
dc.identifier.otherPURE UUID: cd606c2d-a712-4838-a4f7-7119d9e33f07
dc.identifier.otherScopus: 105003558236
dc.identifier.urihttp://hdl.handle.net/10362/183107
dc.identifier.urlhttps://www.scopus.com/pages/publications/105003558236
dc.language.isoeng
dc.peerreviewedyes
dc.subjectaquaporins
dc.subjectepithelial–mesenchymal transition
dc.subjectMAPK/ERK signaling pathway
dc.subjectpancreatic cancer
dc.subjecttranscriptomics
dc.subjectBiochemistry
dc.subjectMolecular Biology
dc.subjectSDG 3 - Good Health and Well-being
dc.titleThe Association of Aquaporins with MAPK Signaling Pathway Unveils Potential Prognostic Biomarkers for Pancreatic Canceren
dc.title.subtitleA Transcriptomics Approachen
dc.typejournal article
degois.publication.issue4
degois.publication.titleBiomolecules
degois.publication.volume15
dspace.entity.typePublication
person.familyNameVieira da Silva
person.familyNameLopes
person.familyNameVigia
person.familyNamePaulino
person.familyNameSoveral
person.givenNameInês
person.givenNamePaula Alexandra
person.givenNameEmanuel
person.givenNameJorge
person.givenNameGraça
person.identifier1068794
person.identifier246647
person.identifier.ciencia-idE918-DF3E-1A17
person.identifier.ciencia-id7A15-519E-7FEF
person.identifier.ciencia-id2114-D43A-FDD9
person.identifier.orcid0000-0002-2916-4848
person.identifier.orcid0000-0002-6755-4572
person.identifier.orcid0000-0002-4525-9062
person.identifier.orcid0000-0002-8491-2802
person.identifier.orcid0000-0001-8487-110X
person.identifier.ridW-7385-2018
person.identifier.ridL-1550-2013
person.identifier.scopus-author-id36862771200
person.identifier.scopus-author-id56328156200
person.identifier.scopus-author-id6602417900
rcaap.rightsopenAccess
relation.isAuthorOfPublicationd13e04a6-2954-469f-9ce5-8ae63ca7575b
relation.isAuthorOfPublicationfc202871-b008-4d02-8b12-23a0c518c376
relation.isAuthorOfPublication965f0565-c665-4f58-870d-2a93b2a8a345
relation.isAuthorOfPublicationa5b91685-b548-4584-9478-354702e96093
relation.isAuthorOfPublication094770be-8a45-4e35-8c1d-41170844ea18
relation.isAuthorOfPublication.latestForDiscovery094770be-8a45-4e35-8c1d-41170844ea18

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