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New Forms of Neuroactive Phospholipids for DHA Enrichment in Brain

2024-02-29Artigo científico Acesso aberto
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dc.contributor.authorGomes, Romina
dc.contributor.authorMendes, Inês
dc.contributor.authorDuarte, Maria Paula
dc.contributor.authorBandarra, Narcisa M.
dc.contributor.authorGomes, Ana Sara
dc.contributor.institutionDQ - Departamento de Química
dc.contributor.institutionMEtRICS - Centro de Engenharia Mecânica e Sustentabilidade de Recursos
dc.contributor.pblMDPI - Multidisciplinary Digital Publishing Institute
dc.date.accessioned2024-09-25T22:26:40Z
dc.date.available2024-09-25T22:26:40Z
dc.date.issued2024-02-29
dc.descriptionThis work was supported by FCT (Fundação para a Ciência e a Tecnologia) under the project PTDC/SAUNUT/30455/2017. Publisher Copyright: © 2024 by the authors.
dc.description.abstractLow levels of docosahexaenoic acid (DHA) in the brain have been related to neurological disorders, like Alzheimer’s disease (AD). After ingestion, dietary DHA must cross the blood–brain barrier, where it is absorbed as lysophosphatidylcholine (LPC), due to its role as a preferential DHA carrier in the brain. This work aimed at the production of LPC-DHA extracts to be used in supplementation/food fortification intended neural enrichment in DHA. As it is rich in DHA, especially its phospholipids (PL), Atlantic mackerel (Scomber scombrus, caught in Spring/2022) was used as a raw material. The polar lipids fraction was separated and hydrolysed with Rhizomucor miehei lipase, to enzymatically convert phosphatidylcholine (PC) into LPC. The fish (muscle and by-products) lipids fraction was used for total lipids (TL) content, lipid classes (LC) and fatty acid (FA) profile evaluation, whilst polar lipids extracts were studied for LC production and FA analysis. Muscle TL ranged between 1.45 and 4.64 g/100 g (WW), while by-products accounted for 7.56-8.96 g/100 g, with the highest contents being found in March. However, PL were more abundant in muscle (22.46–32.20% of TL). For polar lipids extracts, PL represented 50.79% of TL, among which PC corresponded to 57.76% and phosphatidylethanolamine to 42.24%. After hydrolysis, nearly half of this PC was converted into LPC. When compared to the initial PC, DHA relative content (33.6% of total FA) was significantly higher after hydrolysis: 55.6% in PC and 73.6% in LPC. Such extract, obtained from this undervalued species, may represent a promising strategy to increase DHA uptake into brain cells while allowing this species to upgrade.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent19
dc.format.extent910075
dc.identifier.doi10.3390/md22030116
dc.identifier.issn1660-3397
dc.identifier.otherPURE: 99741829
dc.identifier.otherPURE UUID: 0e242f69-fa4f-449c-aec4-6eea8d95638a
dc.identifier.otherScopus: 85188954569
dc.identifier.otherWOS: 001192795500001
dc.identifier.otherPubMed: 38535457
dc.identifier.otherPubMedCentral: PMC10971477
dc.identifier.urihttp://hdl.handle.net/10362/172406
dc.identifier.urlhttps://www.scopus.com/pages/publications/85188954569
dc.language.isoeng
dc.peerreviewedyes
dc.relationFunding Information: info:eu-repo/grantAgreement/FCT/DL 57%2F2016/DL57%2F2016%2FCP1334%2FCP1644%2FCT0001/PT
dc.relationinfo:eu-repo/grantAgreement/FCT//2021.05300.BD/PT
dc.subjectAlzheimer’s disease (AD)
dc.subjectAtlantic mackerel (Scomber scombrus)
dc.subjectdocosahexaenoic acid (DHA)
dc.subjectlysophosphatidylcholine
dc.subjectphospholipids
dc.subjectPharmaceutical Science
dc.subjectDrug Discovery
dc.subjectPharmacology, Toxicology and Pharmaceutics (miscellaneous)
dc.titleNew Forms of Neuroactive Phospholipids for DHA Enrichment in Brainen
dc.typejournal article
degois.publication.issue3
degois.publication.titleMarine Drugs
degois.publication.volume22
dspace.entity.typePublication
oaire.awardNumber2021.05300.BD
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//2021.05300.BD/PT
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccess
relation.isProjectOfPublication14f2ac6d-8960-4688-9ed8-2d4f6ea9c1ed
relation.isProjectOfPublication.latestForDiscovery14f2ac6d-8960-4688-9ed8-2d4f6ea9c1ed

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