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Translating physiology of the arterial chemoreflex into novel therapeutic interventions targeting carotid bodies in cardiometabolic disorders

2025-05-01Recensão Acesso aberto
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dc.contributor.authorŻera, Tymoteusz
dc.contributor.authorPaleczny, Bartłomiej
dc.contributor.authorSiński, Maciej
dc.contributor.authorConde, Sílvia V
dc.contributor.authorV Conde, Silvia
dc.contributor.authorNarkiewicz, Krzysztof
dc.contributor.authorPonikowski, Piotr
dc.contributor.authorPaton, Julian F R
dc.contributor.authorNiewiński, Piotr
dc.contributor.institutionNOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
dc.contributor.institutioniNOVA4Health - pólo NMS
dc.contributor.pblBlackwell Publishing Ltd
dc.date.accessioned2025-04-14T21:12:23Z
dc.date.available2025-04-14T21:12:23Z
dc.date.issued2025-05-01
dc.description© 2025 The Author(s). The Journal of Physiology published by John Wiley & Sons Ltd on behalf of The Physiological Society.
dc.description.abstractThis review resulted from a conference on the pathological role of arterial chemoreflex and carotid bodies in cardiometabolic diseases held at the 27th Congress of the Polish Cardiac Society in September 2023 in Poznan, Poland. It reflects the contribution of Polish researchers and their international collaborations, which have been fundamental in the development of the field. Aberrant activity of the carotid bodies leads to both high tonicity and increased sensitivity of the arterial chemoreflex with resultant sympathoexcitation in chronic heart failure, resistant hypertension and obstructive sleep apnoea. This observation has led to several successful attempts of removing or denervating the carotid bodies as a therapeutic option in humans. Regrettably, such interventions are accompanied by serious respiratory and acid-base balance side-effects. Rather than a single stereotyped reaction, arterial chemoreflex comprises an integrative multi-system response to a variety of stimulants and its specific reflex components may be individually conveyed at varying intensities. Recent research has revealed that carotid bodies express diverse receptors, synthesize a cocktail of mediators, and respond to a plethora of metabolic, hormonal and autonomic nervous stimuli. This state-of-the-art summary discusses exciting new discoveries regarding GLP-1 receptors, purinergic receptors, the glutamate-GABA system, efferent innervation and regulation of blood flow in the carotid body and how they open new avenues for novel pharmacological treatments selectively targeting specific receptors, mediators and neural pathways to correct distinct responses of the carotid body-evoked arterial chemoreflex in cardiometabolic diseases. The carotid body offers novel and advantageous therapeutic opportunities for future consideration by trialists.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent2638666
dc.identifier.doi10.1113/JP285081
dc.identifier.issn0022-3751
dc.identifier.otherPURE: 114952691
dc.identifier.otherPURE UUID: c239f1f5-7299-494d-bb7e-7259ee4687f2
dc.identifier.otherPubMed: 40186613
dc.identifier.otherScopus: 105002397355
dc.identifier.urihttp://hdl.handle.net/10362/182288
dc.language.isoeng
dc.peerreviewedyes
dc.subjectcarotid body
dc.subjectdiabetes mellitus
dc.subjectheart failure
dc.subjecthyperglycaemia
dc.subjecthypertension
dc.subjecthypoxia
dc.subjectsleep apnoea
dc.subjectsympathetic nervous system
dc.titleTranslating physiology of the arterial chemoreflex into novel therapeutic interventions targeting carotid bodies in cardiometabolic disordersen
dc.typereview
degois.publication.firstPage2487
degois.publication.issue9
degois.publication.lastPage2516
degois.publication.titleThe Journal of Physiology
degois.publication.volume603
dspace.entity.typePublication
person.familyNameVilares Conde
person.givenNameSilvia
person.identifier154176
person.identifier.ciencia-id561E-CF29-600A
person.identifier.orcid0000-0002-5920-5700
person.identifier.scopus-author-id7004283202
rcaap.rightsopenAccess
relation.isAuthorOfPublication898e99d8-61a5-44bc-878a-5e1ac44ca37c
relation.isAuthorOfPublication.latestForDiscovery898e99d8-61a5-44bc-878a-5e1ac44ca37c

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