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Murine glial protrusion transcripts predict localized Drosophila glial mRNAs involved in plasticity

2024-10-07Artigo científico Acesso aberto
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dc.contributor.authorLee, Jeffrey Y.
dc.contributor.authorGala, Dalia S.
dc.contributor.authorKiourlappou, Maria
dc.contributor.authorOlivares-Abril, Julia
dc.contributor.authorJoha, Jana
dc.contributor.authorTitlow, Joshua S.
dc.contributor.authorTeodoro, Rita O.
dc.contributor.authorTeodoro, Rita
dc.contributor.authorDavis, Ilan
dc.contributor.institutionNOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
dc.contributor.pblRockefeller University Press
dc.date.accessioned2024-07-31T22:15:21Z
dc.date.available2024-07-31T22:15:21Z
dc.date.issued2024-10-07
dc.descriptionPublisher Copyright: © 2024 Lee et al.
dc.description.abstractThe polarization of cells often involves the transport of specific mRNAs and their localized translation in distal projections. Neurons and glia are both known to contain long cytoplasmic processes, while localized transcripts have only been studied extensively in neurons, not glia, especially in intact nervous systems. Here, we predict 1,740 localized Drosophila glial transcripts by extrapolating from our meta-analysis of seven existing studies characterizing the localized transcriptomes and translatomes of synaptically associated mammalian glia. We demonstrate that the localization of mRNAs in mammalian glial projections strongly predicts the localization of their high-confidence Drosophila homologs in larval motor neuron-associated glial projections and are highly statistically enriched for genes associated with neurological diseases. We further show that some of these localized glial transcripts are specifically required in glia for structural plasticity at the nearby neuromuscular junction synapses. We conclude that peripheral glial mRNA localization is a common and conserved phenomenon and propose that it is likely to be functionally important in disease.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent6733980
dc.identifier.doi10.1083/jcb.202306152
dc.identifier.issn0021-9525
dc.identifier.otherPURE: 96217531
dc.identifier.otherPURE UUID: e6ba54b1-bb98-46b3-9c57-330e77dad0ea
dc.identifier.otherScopus: 85199357989
dc.identifier.otherPubMed: 39037431
dc.identifier.urihttp://hdl.handle.net/10362/170217
dc.identifier.urlhttps://www.scopus.com/pages/publications/85199357989
dc.language.isoeng
dc.peerreviewedyes
dc.subjectCell Biology
dc.titleMurine glial protrusion transcripts predict localized Drosophila glial mRNAs involved in plasticityen
dc.typejournal article
degois.publication.issue10
degois.publication.titleThe Journal of cell biology
degois.publication.volume223
dspace.entity.typePublication
person.familyNameTeodoro
person.givenNameRita
person.identifier1742791
person.identifier.ciencia-idFA14-E92F-75FE
person.identifier.orcid0000-0002-0600-8842
person.identifier.scopus-author-id6603695636
rcaap.rightsopenAccess
relation.isAuthorOfPublicationf73aff78-260d-4658-9eb3-22eb4123e70a
relation.isAuthorOfPublication.latestForDiscoveryf73aff78-260d-4658-9eb3-22eb4123e70a

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