Logo do repositório
 
Publicação

Drugs with a negative impact on cognitive functions (part 3)

2024-08-01Recensão Acesso aberto
Ver registo simples
dc.contributor.authorLiabeuf, Sophie
dc.contributor.authorLiabeuf, Sophie
dc.contributor.authorHafez, Gaye
dc.contributor.authorPešić, Vesna
dc.contributor.authorSpasovski, Goce
dc.contributor.authorSpasovski, Goce
dc.contributor.authorBobot, Mickaël
dc.contributor.authorMickaël Bobot, MD, PhD
dc.contributor.authorMačiulaitis, Romaldas
dc.contributor.authorBumblyte, Inga Arune
dc.contributor.authorFerreira, Ana Carina
dc.contributor.authorFerreira, Ana Carina
dc.contributor.authorFarinha, Ana
dc.contributor.authorMalyszko, Jolanta
dc.contributor.authorPépin, Marion
dc.contributor.authorPépin, Marion
dc.contributor.authorMassy, Ziad A.
dc.contributor.authorMassy, Ziad
dc.contributor.authorUnwin, Robert
dc.contributor.authorUnwin, Robert
dc.contributor.authorCapasso, Giovambattista
dc.contributor.authorCapasso, Giovambattista
dc.contributor.authorMani, Laila Yasmin
dc.contributor.authorMani, Laila-Yasmin
dc.contributor.institutionNOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
dc.contributor.pblOxford University Press
dc.date.accessioned2024-10-08T23:06:31Z
dc.date.available2024-10-08T23:06:31Z
dc.date.issued2024-08-01
dc.descriptionFunding Information: The authors would like to thank Prof. Giovambattista Capasso, acting chair of Cognitive Decline in Nephro-Neurology: European Cooperative Target (CONNECT) Action and members of COST Action for their support. This article is published as financially supported by the Horizon EU COST Action CA19127-Cognitive Decline in Nephro-Neurology: European Cooperative Target (CONNECT). Publisher Copyright: © The Author(s) 2024.
dc.description.abstractThe relationship between chronic kidney disease (CKD) and cognitive function has received increased attention in recent years. Antibacterial agents (ABs) represent a critical component of therapy regimens in patients with CKD due to increased susceptibility to infections. Following our reviewing work on the neurocognitive impact of long-term medications in patients with CKD, we propose to focus on AB-induced direct and indirect consequences on cognitive function. Patients with CKD are predisposed to adverse drug reactions (ADRs) due to altered drug pharmacokinetics, glomerular filtration decline, and the potential disruption of the blood–brain barrier. ABs have been identified as a major cause of ADRs in vulnerable patient populations. This review examines the direct neurotoxic effects of AB classes (e.g. beta-lactams, fluoroquinolones, aminoglycosides, and metronidazole) on the central nervous system (CNS) in patients with CKD. We will mainly focus on the acute effects on the CNS associated with AB since they are the most extensively studied effects in CKD patients. Moreover, the review describes the modulation of the gut microbiota by ABs, potentially influencing CNS symptoms. The intricate brain–gut–kidney axis emerges as a pivotal focus, revealing the interplay between microbiota alterations induced by ABs and CNS manifestations in patients with CKD. The prevalence of antibiotic-associated encephalopathy in patients with CKD undergoing intravenous AB therapy supports the use of therapeutic drug monitoring for ABs to reduce the number and seriousness of ADRs in this patient population. In conclusion, elucidating AB-induced cognitive effects in patients with CKD demands a comprehensive understanding and tailored therapeutic strategies that account for altered pharmacokinetics and the brain–gut–kidney axis.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent2300450
dc.identifier.doi10.1093/ckj/sfae174
dc.identifier.issn2048-8505
dc.identifier.otherPURE: 100881129
dc.identifier.otherPURE UUID: fc6e25eb-dc84-42ec-950b-0c60ba238d71
dc.identifier.otherScopus: 85200854899
dc.identifier.urihttp://hdl.handle.net/10362/173205
dc.identifier.urlhttps://www.scopus.com/pages/publications/85200854899
dc.language.isoeng
dc.peerreviewedyes
dc.subjectadverse drug reactions
dc.subjectantibacterial agents
dc.subjectchronic kidney disease
dc.subjectcognitive impairment
dc.subjectdrugs
dc.subjectNephrology
dc.subjectTransplantation
dc.titleDrugs with a negative impact on cognitive functions (part 3)en
dc.title.subtitleantibacterial agents in patients with chronic kidney diseaseen
dc.typereview
degois.publication.issue8
degois.publication.titleClinical kidney journal
degois.publication.volume17
dspace.entity.typePublication
person.familyNameliabeuf
person.familyNameSpasovski
person.familyNameBobot
person.familyNameFerreira
person.familyNamePépin
person.familyNamemassy
person.familyNameUnwin
person.familyNameCapasso
person.familyNameMani
person.givenNamesophie
person.givenNameGoce
person.givenNameMickaël
person.givenNameAna Carina
person.givenNameMarion
person.givenNameziad
person.givenNameRobert
person.givenNameGiovambattista
person.givenNameLaila-Yasmin
person.identifier813406
person.identifier580711
person.identifier.ciencia-idA318-2E3A-51CE
person.identifier.orcid0000-0001-5384-9006
person.identifier.orcid0000-0001-5628-2500
person.identifier.orcid0000-0002-9451-0372
person.identifier.orcid0000-0002-1323-5293
person.identifier.orcid0000-0002-3064-2480
person.identifier.orcid0000-0001-5771-5996
person.identifier.orcid0000-0001-7839-6031
person.identifier.orcid0000-0003-3469-8614
person.identifier.orcid0000-0002-4693-7814
person.identifier.ridAAR-5310-2021
person.identifier.scopus-author-id35515598400
person.identifier.scopus-author-id35599101500
rcaap.rightsopenAccess
relation.isAuthorOfPublication9a19a087-a1b0-4f2a-b9ee-a7f9de8ba527
relation.isAuthorOfPublication058520a1-a664-4cb3-8c79-ad17fcacf1c5
relation.isAuthorOfPublicationfc8b0d0b-37ce-4f30-89af-19a737c655fa
relation.isAuthorOfPublication7c73ab0a-eee5-4ee5-be37-cdbd5dc942fa
relation.isAuthorOfPublication41c89146-24a2-418f-b79e-ce35b12976b0
relation.isAuthorOfPublicationd4ec98fe-b294-4368-a265-798d2126439b
relation.isAuthorOfPublication791db3a4-0063-48e5-b874-bb4b9b7c5a40
relation.isAuthorOfPublication7ec98f40-c321-4e83-83e3-aa804d9bc8b6
relation.isAuthorOfPublicatione8ff28c5-0dd4-4ee1-9895-5fdc82baaca8
relation.isAuthorOfPublication.latestForDiscovery791db3a4-0063-48e5-b874-bb4b9b7c5a40

Ficheiros

Principais
A mostrar 1 - 1 de 1
Miniatura
Nome:
sfae174.pdf
Tamanho:
2.19 MB
Formato:
Adobe Portable Document Format
Ver/Abrir

Coleções

NMS - Artigos em revista internacional com arbitragem científica