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Comprehensive Landscape of STEAP Family Members Expression in Human Cancers

2022-05-11Artigo científico Acesso aberto
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dc.contributor.authorRocha, Sandra M.
dc.contributor.authorSocorro, Sílvia
dc.contributor.authorPassarinha, Luís A.
dc.contributor.authorMaia, Cláudio J.
dc.contributor.institutionUCIBIO - Applied Molecular Biosciences Unit
dc.contributor.institutionDQ - Departamento de Química
dc.contributor.pblMDPI - Multidisciplinary Digital Publishing Institute
dc.date.accessioned2022-10-06T22:16:33Z
dc.date.available2022-10-06T22:16:33Z
dc.date.issued2022-05-11
dc.descriptionProject No. 007491 Project No. 029114 LA/P/0140/2020 Centro-01-0145-FEDER-000019-C4
dc.description.abstractThe human Six-Transmembrane Epithelial Antigen of the Prostate (STEAP) family com-prises STEAP1-4. Several studies have pointed out STEAP proteins as putative biomarkers, as well as therapeutic targets in several types of human cancers, particularly in prostate cancer. However, the relationships and significance of the expression pattern of STEAP1-4 in cancer cases are barely known. Herein, the Oncomine database and cBioPortal platform were selected to predict the differential expression levels of STEAP members and clinical prognosis. The most common expression pattern observed was the combination of the over-and underexpression of distinct STEAP genes, but cervical and gastric cancer and lymphoma showed overexpression of all STEAP genes. It was also found that STEAP genes’ expression levels were already deregulated in benign lesions. Regarding the prognostic value, it was found that STEAP1 (prostate), STEAP2 (brain and central nervous system), STEAP3 (kidney, leukemia and testicular) and STEAP4 (bladder, cervical, gastric) overexpression correlate with lower patient survival rate. However, in prostate cancer, overexpression of the STEAP4 gene was correlated with a higher survival rate. Overall, this study first showed that the expression levels of STEAP genes are highly variable in human cancers, which may be related to different patients’ outcomes.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent48
dc.format.extent2760355
dc.identifier.doi10.3390/data7050064
dc.identifier.issn2306-5729
dc.identifier.otherPURE: 46297629
dc.identifier.otherPURE UUID: 9ea2cbda-73e2-426b-a92b-57e39eaae46f
dc.identifier.otherScopus: 85130524735
dc.identifier.otherWOS: 000802723200001
dc.identifier.urihttp://hdl.handle.net/10362/144510
dc.identifier.urlhttps://www.scopus.com/pages/publications/85130524735
dc.language.isoeng
dc.peerreviewedyes
dc.relationinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00709%2F2020/PT
dc.relationHealth Sciences Research Centre
dc.relationApplied Molecular Biosciences Unit
dc.relationApplied Molecular Biosciences Unit
dc.subjectcBioPortal
dc.subjecthuman cancers
dc.subjectOncomine
dc.subjectprognosis
dc.subjectSTEAP members
dc.subjectInformation Systems
dc.subjectComputer Science Applications
dc.subjectInformation Systems and Management
dc.subjectSDG 3 - Good Health and Well-being
dc.titleComprehensive Landscape of STEAP Family Members Expression in Human Cancersen
dc.title.subtitleUnraveling the Potential Usefulness in Clinical Practice Using Integrated Bioinformatics Analysisen
dc.typejournal article
degois.publication.issue5
degois.publication.titleData
degois.publication.volume7
dspace.entity.typePublication
oaire.awardNumberUIDB/00709/2020
oaire.awardNumberUIDB/04378/2020
oaire.awardNumberUIDP/04378/2020
oaire.awardTitleHealth Sciences Research Centre
oaire.awardTitleApplied Molecular Biosciences Unit
oaire.awardTitleApplied Molecular Biosciences Unit
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00709%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04378%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F04378%2F2020/PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccess
relation.isProjectOfPublicatione7002a6a-1e2f-4df7-a57f-d88175c907ea
relation.isProjectOfPublicatione07cf232-4705-4b5b-b2c4-af8f25311076
relation.isProjectOfPublication38373452-5c9c-4724-8def-f03314ecce0e
relation.isProjectOfPublication.latestForDiscoverye07cf232-4705-4b5b-b2c4-af8f25311076

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