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How to use human biomonitoring in chemical risk assessment

2023-04Artigo científico Acesso aberto
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dc.contributor.authorSantonen, Tiina
dc.contributor.authorMahiout, Selma
dc.contributor.authorAlvito, Paula
dc.contributor.authorApel, Petra
dc.contributor.authorBessems, Jos
dc.contributor.authorBil, Wieneke
dc.contributor.authorBorges, Teresa
dc.contributor.authorBose-O'Reilly, Stephan
dc.contributor.authorBuekers, Jurgen
dc.contributor.authorCañas Portilla, Ana Isabel
dc.contributor.authorCalvo, Argelia Castaño
dc.contributor.authorde Alba González, Mercedes
dc.contributor.authorDomínguez-Morueco, Noelia
dc.contributor.authorLópez, Marta Esteban
dc.contributor.authorFalnoga, Ingrid
dc.contributor.authorGerofke, Antje
dc.contributor.authorCaballero, María Del Carmen González
dc.contributor.authorHorvat, Milena
dc.contributor.authorHuuskonen, Pasi
dc.contributor.authorKadikis, Normunds
dc.contributor.authorKolossa-Gehring, Marike
dc.contributor.authorLange, Rosa
dc.contributor.authorLouro, Henriqueta
dc.contributor.authorMartins, Carla
dc.contributor.authorMeslin, Matthieu
dc.contributor.authorNiemann, Lars
dc.contributor.authorDíaz, Susana Pedraza
dc.contributor.authorPlichta, Veronika
dc.contributor.authorPorras, Simo P
dc.contributor.authorRousselle, Christophe
dc.contributor.authorScholten, Bernice
dc.contributor.authorSilva, Maria João
dc.contributor.authorŠlejkovec, Zdenka
dc.contributor.authorTratnik, Janja Snoj
dc.contributor.authorJoksić, Agnes Šömen
dc.contributor.authorTarazona, Jose V
dc.contributor.authorUhl, Maria
dc.contributor.authorVan Nieuwenhuyse, An
dc.contributor.authorViegas, Susana
dc.contributor.authorVinggaard, Anne Marie
dc.contributor.authorWoutersen, Marjolijn
dc.contributor.authorSchoeters, Greet
dc.contributor.institutionCentre for Toxicogenomics and Human Health (ToxOmics)
dc.contributor.institutionNOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
dc.contributor.institutionCentro de Investigação em Saúde Pública (CISP/PHRC)
dc.contributor.institutionComprehensive Health Research Centre (CHRC) - Pólo ENSP
dc.contributor.institutionEscola Nacional de Saúde Pública (ENSP)
dc.contributor.pblElsevier Science B.V., Amsterdam.
dc.date.accessioned2023-03-13T22:26:02Z
dc.date.available2023-03-13T22:26:02Z
dc.date.issued2023-04
dc.descriptionFunding: This project received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 733032 HBM4EU, and co-funding from the authors’ organisations. The results presented here are based on a huge body of work performed as part of Task 5.3 of the HBM4EU in 2017–2022. First and foremost, we would like to acknowledge all our Task 5.3 colleagues for their valuable contribution to the project work, including the individual RAs and EBoD calculations. In addition, we would like to thank all our other HBM4EU colleagues, the HBM4EU-aligned study data owners, and the other stakeholders who provided support for and feedback on our work during its course.
dc.description.abstractOne of the aims of the European Human Biomonitoring Initiative, HBM4EU, was to provide examples of and good practices for the effective use of human biomonitoring (HBM) data in human health risk assessment (RA). The need for such information is pressing, as previous research has indicated that regulatory risk assessors generally lack knowledge and experience of the use of HBM data in RA. By recognising this gap in expertise, as well as the added value of incorporating HBM data into RA, this paper aims to support the integration of HBM into regulatory RA. Based on the work of the HBM4EU, we provide examples of different approaches to including HBM in RA and in estimations of the environmental burden of disease (EBoD), the benefits and pitfalls involved, information on the important methodological aspects to consider, and recommendations on how to overcome obstacles. The examples are derived from RAs or EBoD estimations made under the HBM4EU for the following HBM4EU priority substances: acrylamide, o-toluidine of the aniline family, aprotic solvents, arsenic, bisphenols, cadmium, diisocyanates, flame retardants, hexavalent chromium [Cr(VI)], lead, mercury, mixture of per-/poly-fluorinated compounds, mixture of pesticides, mixture of phthalates, mycotoxins, polycyclic aromatic hydrocarbons (PAHs), and the UV-filter benzophenone-3. Although the RA and EBoD work presented here is not intended to have direct regulatory implications, the results can be useful for raising awareness of possibly needed policy actions, as newly generated HBM data from HBM4EU on the current exposure of the EU population has been used in many RAs and EBoD estimations.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent1175354
dc.identifier.doi10.1016/j.ijheh.2023.114139
dc.identifier.issn1438-4639
dc.identifier.otherPURE: 54916338
dc.identifier.otherPURE UUID: 315e42ba-49eb-4e1c-a85b-f2c0f5fecd09
dc.identifier.otherPubMed: 36870229
dc.identifier.otherORCID: /0000-0001-7930-2914/work/130765886
dc.identifier.otherScopus: 85149275549
dc.identifier.urihttp://hdl.handle.net/10362/150480
dc.language.isoeng
dc.peerreviewedyes
dc.subjectChemicals
dc.subjectEnvironmental burden of disease
dc.subjectExposure biomarkers
dc.subjectHBM4EU
dc.subjectHuman biomonitoring
dc.subjectRisk assessment
dc.subjectSDG 3 - Good Health and Well-being
dc.titleHow to use human biomonitoring in chemical risk assessmenten
dc.title.subtitleMethodological aspects, recommendations, and lessons learned from HBM4EUen
dc.typejournal article
degois.publication.titleInternational Journal Of Hygiene And Environmental Health
degois.publication.volume249
dspace.entity.typePublication
rcaap.rightsopenAccess

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