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Anti-cyclic citrullinated peptide antibodies and rheumatoid factor in Sjögren's syndrome

2009-10Artigo científico Acesso aberto
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dc.contributor.authorBarcelos, Filipe
dc.contributor.authorAbreu, Isabel
dc.contributor.authorPatto, José Vaz
dc.contributor.authorTrindade, Helder
dc.contributor.authorTeixeira, Ana
dc.contributor.institutionNOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
dc.contributor.pblSociedade Portuguesa de Reumatologia
dc.date.accessioned2017-07-17T22:00:40Z
dc.date.available2017-07-17T22:00:40Z
dc.date.issued2009-10
dc.description.abstractObjectives: The purpose of this study was to evaluate the prevalence and clinical significance of anti-cyclic citrullinated peptide antibodies (anti-CCP-Abs), IgM and IgA rheumatoid factors (RFs) in primary Sjogren's Syndrome (pSS). Materials and Methods:We compared clinical and serological. characteristics of 31 pSS and 31 Rheumatoid Arthritis (RA) patients. Both, anti-CCP-Abs and RFs (IgM, IgA) directed against Fc determinants of IgG from humans and rabbit were detected by enzyme-linked immunosorbent assay (ELISA). We included 31 blood donors as control group for the evaluation of RFs and anti-CCP-Abs. Nine (29%) pSS patients presented arthritis, and 10 (32,3%) RA patients also had secondary Sjogren's syndrome (sSS) Results: IgM and IgA RFs prevalence was similar in pSS and RA, whichever the antigene (Human or Rabbit IgG) used. However, RA patients with sSS showed a tendency to present more often RF positivity, longer disease duration and higher ESR and CRP when compared with pSS patients with arthritis. Anti-CCP-Abs were detected in 64,5% of RA patients and in only 6,9% of pSS patients (p<0,0005). Anti-CCP-Abs were more often positive in RA patients with sSS (RA/sSS) (8 patients, 80%) than in RA patients without sSS (18 patients, 58,1%), and were absent in pSS patients with arthritis. RF-positive pSS patients presented more often pulmonary involvement and higher inflammatory parameters, and less often neuropathy compared to RF-negative patients. In controls, anti-CCP-Abs were absent and REs were negligible. Conclusions: Anti-CCP-Abs were detected in only a few pSS patients, none of whom presented arthritis, which contrasts with the high frequency of these antibodies in RA/sSS. These results suggest that anti-CCP-Abs could be useful in the distinction between pSS and RA with sSS. Although not useful for the differential diagnosis between RA and pSS, RFs may have a prognostic role in pSS.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent5
dc.format.extent73405
dc.identifier.issn0303-464X
dc.identifier.otherPURE: 291953
dc.identifier.otherPURE UUID: 6b3f7ece-6604-4237-8453-de425299d0cb
dc.identifier.otherresearchoutputwizard: 13287
dc.identifier.otherPubMed: 20087267
dc.identifier.otherWOS: 000273749400005
dc.identifier.otherScopus: 79952112001
dc.identifier.urihttp://hdl.handle.net/10362/22009
dc.language.isoeng
dc.peerreviewedyes
dc.subjectIGM
dc.subjectRheumatoidArthritisCLINICAL-SIGNIFICANCE
dc.subjectELISA ASSAYS
dc.subjectAnti-CCP Antibodies
dc.subjectRheumatoid Factors
dc.subjectPREVALENCE
dc.subjectSjogren's Syndrome
dc.subjectDISEASE
dc.subjectARTHRITIS
dc.subjectAUTOANTIBODIES
dc.subjectSjögren’s Syndrome
dc.subjectAnti-CCP Antibodies
dc.subjectRheumatoid Factors
dc.subjectRheumatoid Arthritis
dc.subjectSDG 3 - Good Health and Well-being
dc.titleAnti-cyclic citrullinated peptide antibodies and rheumatoid factor in Sjögren's syndromeen
dc.typejournal article
degois.publication.firstPage608
degois.publication.issue4
degois.publication.lastPage612
degois.publication.titleActa Reumatológica Portuguesa
degois.publication.volume34
dspace.entity.typePublication
rcaap.rightsopenAccess

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