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MMPs at Work

2026-01-05Recensão Acesso aberto
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dc.contributor.authorPatrão, Mariana Ramos
dc.contributor.authorPereira, Pedro Mariano
dc.contributor.authorCaldeira, Jorge
dc.contributor.authorSalema-Oom, Madalena
dc.contributor.institutionLAQV@REQUIMTE
dc.contributor.pblMDPI - Multidisciplinary Digital Publishing Institute
dc.date.accessioned2026-03-19T16:13:01Z
dc.date.available2026-03-19T16:13:01Z
dc.date.issued2026-01-05
dc.descriptionPublisher Copyright: © 2026 by the authors.
dc.description.abstractMatrix metallopeptidases (MMPs) are enzymes that, in balance with their inhibitors, play a vital role in extracellular matrix remodelling, particularly during orthodontic tooth movement (OTM). Despite growing interest, significant research is still required to fully comprehend the mechanisms and signalling pathways involved in periodontal ligament remodelling and OTM, particularly those mediated by MMPs. This review explores recent in vitro and in vivo evidence on how specific MMPs—namely, MMP-1, -2, -3, -8, -9, -12, -13, and -14—respond to compressive and tensile forces, regulate collagen degradation, and influence periodontal ligament fibroblast and osteoblast behaviour, ultimately shaping tissue resorption and formation. We also summarize the roles of periodontal ligament cells, hypoxia, the neurovascular and immune systems, and well-known molecules—including receptor activator of nuclear factor kappa β, receptor activator of nuclear factor kappa β ligand, osteoprotegerin, macrophage colony-stimulating factor, tumour necrosis factor α, transforming growth factor, and interleukins—in orchestrating these responses. Finally, we address the clinical relevance of these pathways, highlighting the potential for therapeutic strategies targeting MMPs activity. Overall, this review underscores the pivotal contribution of MMPs to extracellular matrix turnover and tissue adaptation during OTM and suggests that modulating the MMPs/tissue inhibitors of matrix metallopeptidase (TIMPs) balance may enhance orthodontic outcomes.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent23
dc.format.extent1295264
dc.identifier.doi10.3390/ijms27010542
dc.identifier.issn1661-6596
dc.identifier.otherPURE: 157103189
dc.identifier.otherPURE UUID: f08b56c4-edbe-4823-81b7-de90feb6ceca
dc.identifier.otherScopus: 105027054818
dc.identifier.otherPubMed: 41516413
dc.identifier.otherPubMedCentral: PMC12787207
dc.identifier.otherWOS: 001657399600001
dc.identifier.urihttp://hdl.handle.net/10362/201657
dc.identifier.urlhttps://www.scopus.com/pages/publications/105027054818
dc.identifier.urlhttps://www.webofscience.com/wos/woscc/full-record/WOS:001657399600001
dc.language.isoeng
dc.peerreviewedyes
dc.subjectCompression side
dc.subjectMatrix metallopeptidases
dc.subjectOrthodontic tooth movement
dc.subjectPeriodontal ligament
dc.subjectTension side
dc.subjectCatalysis
dc.subjectMolecular Biology
dc.subjectComputer Science Applications
dc.subjectSpectroscopy
dc.subjectPhysical and Theoretical Chemistry
dc.subjectOrganic Chemistry
dc.subjectInorganic Chemistry
dc.titleMMPs at Worken
dc.title.subtitleDeciphering Their Role in the Cellular Mechanisms of Orthodontic Tooth Movementen
dc.typereview
degois.publication.firstPage1
degois.publication.issue1
degois.publication.lastPage23
degois.publication.titleInternational Journal of Molecular Sciences
degois.publication.volume27
dspace.entity.typePublication
rcaap.rightsopenAccess

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