Logo do repositório
 
Publicação

A review on medicinal plants used for treating ototoxicity and acoustic trauma induced hearing loss

2019Recensão Acesso aberto
Ver registo simples
dc.contributor.authorMahmoudian-Sani, Mohammad Reza
dc.contributor.authorSheikhshabani, Somayeh Hashemi
dc.contributor.authorMirfakhar, Farzaneh Sadat
dc.contributor.authorAsgharzade, Samira
dc.contributor.institutionNOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
dc.contributor.institutionCentro de Estudos de Doenças Crónicas (CEDOC)
dc.contributor.pblFaculdade de Ciencias Farmaceuticas (Biblioteca-
dc.date.accessioned2020-04-16T22:40:04Z
dc.date.available2020-04-16T22:40:04Z
dc.date.issued2019
dc.description.abstractHearing loss induced by chemotherapy and acoustic trauma is mainly associated with two factors, free radical formation and apoptosis pathway activation. Despite numerous efforts on reducing the effects of these factors, no definite strategy is still determined to interfere with and control these processes. In recent studies, various protective agents, including antioxidants have been used on animal models, to inhibit the formation of free radicals thus improving hearing loss.In this review article we will discuss the role of traditional herbal medicine in treatment of noise/drug induced hearing loss, focusing on medicinal plants’ active substances,as well as their mechanisms of action in reducing or preventing the formation of free radicals thus increasing the rate of survival of cochlea cells. Data have been gathered since year 2000, from scientific publications including the following keywords: deafness, drug toxicity, acute trauma, medicinal herbs and oxidative stress. The study includes all herbs and medicinal plants that have been experimentally used in studies on animal models and clinical trials. The results from these studies indicate the effectiveness of most of these herbs and their active substances through their antioxidative properties. Medicinal plants reported in this review can thus be considered as effective remedies intreating noise/drug induced hearing loss,yet further studies need to be done.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent656712
dc.identifier.doi10.1590/s2175-97902019000218311
dc.identifier.issn1984-8250
dc.identifier.otherPURE: 17785937
dc.identifier.otherPURE UUID: 1e32d050-0eff-48c5-ba96-c025527ef527
dc.identifier.otherScopus: 85078362543
dc.identifier.otherWOS: 000524008700001
dc.identifier.urihttp://hdl.handle.net/10362/96353
dc.identifier.urlhttps://www.scopus.com/pages/publications/85078362543
dc.language.isoeng
dc.peerreviewedyes
dc.subjectAcoustic Trauma/ physiopathology
dc.subjectAntioxidants/ therapeutic use
dc.subjectHearing Loss
dc.subjectHearing Loss/ prevention & control
dc.subjectHerbal Medicine/ instrumentation
dc.subjectMedicinal/ drug effects
dc.subjectNoise-Induced/ therapy
dc.subjectOtotoxicity
dc.subjectOxidative stress/ drug effects
dc.subjectPlants
dc.subjectPharmacology, Toxicology and Pharmaceutics(all)
dc.titleA review on medicinal plants used for treating ototoxicity and acoustic trauma induced hearing lossen
dc.typereview
degois.publication.titleBrazilian Journal of Pharmaceutical Sciences
degois.publication.volume55
dspace.entity.typePublication
rcaap.rightsopenAccess

Ficheiros

Principais
A mostrar 1 - 1 de 1
Miniatura
Nome:
2175_9790_bjps_55_e18311.pdf
Tamanho:
641.32 KB
Formato:
Adobe Portable Document Format
Ver/Abrir

Coleções

NMS - Artigos em revista internacional com arbitragem científica