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Evaluating SARS-CoV-2 Seroconversion Following Relieve of Confinement Measures

2020-12-18Artigo científico Acesso aberto
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dc.contributor.authorGonçalves, Juliana
dc.contributor.authorGonçalves, Juliana
dc.contributor.authorSousa, Rita L.
dc.contributor.authorJacinto, Maria J.
dc.contributor.authorSilva, Daniela A.
dc.contributor.authorPaula, Filipe
dc.contributor.authorSousa, Rute
dc.contributor.authorSousa, RD
dc.contributor.authorZahedi, Sara
dc.contributor.authorCarvalho, Joana
dc.contributor.authorCabral, M. Guadalupe
dc.contributor.authorCabral, MG
dc.contributor.authorCosta, Manuela
dc.contributor.authorBranco, Jaime
dc.contributor.authorBranco, Jaime
dc.contributor.authorCanhão, Helena
dc.contributor.authorCanhão, Helena
dc.contributor.authorAlves, José D.
dc.contributor.authorAlves J, Delgado
dc.contributor.authorRodrigues, Ana M.
dc.contributor.authorMaria Rodrigues, Ana
dc.contributor.authorSoares, Helena
dc.contributor.authorSoares, Helena
dc.contributor.institutionNOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
dc.contributor.institutionCentro de Estudos de Doenças Crónicas (CEDOC)
dc.contributor.institutionComprehensive Health Research Centre (CHRC) - pólo NMS
dc.contributor.pblFrontiers Media
dc.date.accessioned2021-01-12T23:24:05Z
dc.date.available2021-01-12T23:24:05Z
dc.date.issued2020-12-18
dc.descriptionFunding: This work was supported by FCT grants (PTDC/MECREU/29520/2017 to HS and CHRC UIDB/4923/2020, UIPD/4923/2020). JG, MJJ, and DAS are supported by FCT through /BD/128343/2017, PTDC/EGE-OGE/32573/2017, and PD/BD/137409/2018, respectively. The anti-SARSCoV-2 ELISA assay was developed within the context of Serology4COVID consortium, in which IBET (Instituto de Biologia Experimental e Tecnológica) produced and purified the Spike protein. This initiative was supported by Calouste Gulbenkian Foundation’s Emergency Fund for COVID-19, Sociedade Francisco Manuel dos Santos and Oeiras Municipality.
dc.description.abstractSeroprevalence studies are crucial both for estimating the prevalence of SARS-CoV-2 exposure and to provide a measure for the efficiency of the confinement measures. Portuguese universities were closed on March 16th 2020, when Portugal only registered 62 SARS-CoV-2 infection cases per million. We have validated a SARS-CoV-2 ELISA assay to a stabilized full-length spike protein using 216 pre-pandemic and 19 molecularly diagnosed SARS-CoV-2 positive individual's samples. At NOVA University of Lisbon, presential work was partially resumed on May 25th with staggered schedules. From June 15th to 30th, 3–4 weeks after the easing of confinement measures, we screened 1,636 collaborators of NOVA university of Lisbon for the presence of SARS-CoV-2 spike specific IgA and IgG antibodies. We found that spike-specific IgG in 50 of 1,636 participants (3.0%), none of which had anti-spike IgA antibodies. As participants self-reported as asymptomatic or paucisymptomatic, our study also provides a measurement of the prevalence of asymptomatic/paucisymptomatic SARS-CoV-2 infections. Our study suggests that essential workers have a 2-fold increase in viral exposure, when compared to non-essential workers that observed confinement. Additional serological surveys in different population subgroups will paint a broader picture of the effect of the confinement measures in the broader community.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent1094808
dc.identifier.doi10.3389/fmed.2020.603996
dc.identifier.issn2296-858X
dc.identifier.otherPURE: 27438864
dc.identifier.otherPURE UUID: 3193a556-1621-4f8f-b7fa-dcb387aba61f
dc.identifier.otherScopus: 85098626868
dc.identifier.otherORCID: /0000-0003-1894-4870/work/86690742
dc.identifier.otherPubMed: 33392225
dc.identifier.otherWOS: 000603981300001
dc.identifier.urihttp://hdl.handle.net/10362/110136
dc.identifier.urlhttps://www.scopus.com/pages/publications/85098626868
dc.language.isoeng
dc.peerreviewedyes
dc.subjectIgA and IgG
dc.subjectpauci/asymptomatic COVID-19 prevalence
dc.subjectpost-confinement community setting
dc.subjectSARS-CoV2
dc.subjectserosurvey
dc.subjectGeneral Medicine
dc.titleEvaluating SARS-CoV-2 Seroconversion Following Relieve of Confinement Measuresen
dc.typejournal article
degois.publication.titleFrontiers in medicine
degois.publication.volume7
dspace.entity.typePublication
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person.familyNameBranco
person.familyNameCanhão
person.familyNameDelgado Alves
person.familyNameRodrigues
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person.givenNameJuliana
person.givenNameRute Dinis de
person.givenNameMaria de Guadalupe
person.givenNameJaime
person.givenNameHelena
person.givenNameJosé
person.givenNameAna Maria
person.givenNameHelena
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rcaap.rightsopenAccess
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