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In Vitro Antimicrobial Studies of Mesoporous Silica Nanoparticles Comprising Anionic Ciprofloxacin Ionic Liquids and Organic Salts

2023-07-12Artigo científico Acesso aberto
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dc.contributor.authorFilipe, Luís
dc.contributor.authorde Sousa, Telma
dc.contributor.authorSilva, Dário
dc.contributor.authorSantos, Miguel M.
dc.contributor.authorRibeiro Carrott, Manuela
dc.contributor.authorPoeta, Patrícia
dc.contributor.authorBranco, Luís C.
dc.contributor.authorGago, Sandra
dc.contributor.institutionLAQV@REQUIMTE
dc.contributor.pblMDPI AG
dc.date.accessioned2023-11-09T22:09:19Z
dc.date.available2023-11-09T22:09:19Z
dc.date.issued2023-07-12
dc.descriptionFunding Information: The NMR spectrometers are part of the National NMR Network (PTNMR) and are partially supported by Infrastructure Project N° 022161 (co-financed by FEDER through COMPETE 2020, POCI and PORL and FCT through PIDDAC). Funding Information: The authors LF and TdS thank FCT/MCTES (Fundação para a Ciência e Tecnologia and Ministério da Ciência, Tecnologia e Ensino Superior) for PhD grants ref. DFA/BD/5332/2020, respectively. Publisher Copyright: © 2023 by the authors.
dc.description.abstractThe combination of active pharmaceutical ingredients in the form of ionic liquids or organic salts (API-OSILs) with mesoporous silica nanoparticles (MSNs) as drug carriers can provide a useful tool in enhancing the capabilities of current antibiotics, especially against resistant strains of bacteria. In this publication, the preparation of a set of three nanomaterials based on the modification of a MSN surface with cholinium ([MSN-Chol][Cip]), 1-methylimidazolium ([MSN-1-MiM][Cip]) and 3-picolinium ([MSN-3-Pic][Cip]) ionic liquids coupled with anionic ciprofloxacin have been reported. All ionic liquids and functionalized nanomaterials were prepared through sustainable protocols, using microwave-assisted heating as an alternative to conventional methods. All materials were characterized through FTIR, solution 1H NMR, elemental analysis, XRD and N2 adsorption at 77 K. The prepared materials showed no in vitro cytotoxicity in fibroblasts viability assays. The minimum inhibitory concentration (MIC) for all materials was tested against Gram-negative K. pneumoniae and Gram-positive Enterococcus spp., both with resistant and sensitive strains. All sets of nanomaterials containing the anionic antibiotic outperformed free ciprofloxacin against resistant and sensitive forms of K. pneumoniae, with the prominent case of [MSN-Chol][Cip] suggesting a tenfold decrease in the MIC against sensitive strains. Against resistant K. pneumoniae, a five-fold decrease in the MIC was observed for all sets of nanomaterials compared with neutral ciprofloxacin. Against Enterococcus spp., only [MSN-1-MiM][Cip] was able to demonstrate a slight improvement over the free antibiotic.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent17
dc.format.extent2386705
dc.identifier.doi10.3390/pharmaceutics15071934
dc.identifier.issn1999-4923
dc.identifier.otherPURE: 75760934
dc.identifier.otherPURE UUID: 2d673300-a352-4b30-ae3a-a6211f84c8cc
dc.identifier.otherScopus: 85166350843
dc.identifier.otherWOS: 001038924500001
dc.identifier.otherPubMed: 37514120
dc.identifier.otherPubMedCentral: PMC10385687
dc.identifier.otherORCID: /0000-0001-8973-1595/work/151389190
dc.identifier.urihttp://hdl.handle.net/10362/159765
dc.identifier.urlhttps://www.scopus.com/pages/publications/85166350843
dc.language.isoeng
dc.peerreviewedyes
dc.relationinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F50006%2F2020/PT
dc.relationAssociated Laboratory for Green Chemistry - Clean Technologies and Processes
dc.relationAssociated Laboratory for Green Chemistry - Clean Technologies and Processes
dc.relationVeterinary and Animal Science Research Centre
dc.relationAssociate Laboratory for Animal and Veterinary Sciences
dc.relationinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/LA%2FP%2F0059%2F2020/PT
dc.relationSilica nanomaterials based on ionic antimicrobial agents for infectious therapeutic diseases
dc.relationinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FQUI-QOR%2F32406%2F2017/PT
dc.relationinfo:eu-repo/grantAgreement/FCT//2021.08347.BD/PT
dc.subjectantibiotic resistance
dc.subjectantimicrobial activity
dc.subjectciprofloxacin
dc.subjectionic liquids
dc.subjectmesoporous silica nanoparticles
dc.subjecttoxicity
dc.subjectPharmaceutical Science
dc.subjectSDG 3 - Good Health and Well-being
dc.titleIn Vitro Antimicrobial Studies of Mesoporous Silica Nanoparticles Comprising Anionic Ciprofloxacin Ionic Liquids and Organic Saltsen
dc.typejournal article
degois.publication.issue7
degois.publication.titlePharmaceutics
degois.publication.volume15
dspace.entity.typePublication
oaire.awardNumberUIDB/50006/2020
oaire.awardNumberUIDP/50006/2020
oaire.awardNumberUIDP/00772/2020
oaire.awardNumberLA/P/0059/2020
oaire.awardNumberPTDC/QUI-QOR/32406/2017
oaire.awardNumber2021.08347.BD
oaire.awardTitleAssociated Laboratory for Green Chemistry - Clean Technologies and Processes
oaire.awardTitleAssociated Laboratory for Green Chemistry - Clean Technologies and Processes
oaire.awardTitleVeterinary and Animal Science Research Centre
oaire.awardTitleAssociate Laboratory for Animal and Veterinary Sciences
oaire.awardTitleSilica nanomaterials based on ionic antimicrobial agents for infectious therapeutic diseases
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F50006%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F50006%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F00772%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/LA%2FP%2F0059%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FQUI-QOR%2F32406%2F2017/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//2021.08347.BD/PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream3599-PPCDT
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