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Multi-step subcritical water extracts of fucus vesiculosus l. And codium tomentosum stackhouse

2021-05-19Artigo científico Acesso aberto
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dc.contributor.authorSoares, Cristina
dc.contributor.authorPaíga, Paula
dc.contributor.authorMarques, M. Manuel B.
dc.contributor.authorNeto, Tânia
dc.contributor.authorCarvalho, Ana Paula
dc.contributor.authorPaiva, Alexandre
dc.contributor.authorSimões, Pedro
dc.contributor.authorCosta, Leonor
dc.contributor.authorBernardo, Ana
dc.contributor.authorFernández, Naiara
dc.contributor.authorPinto, Edgar
dc.contributor.authorAlmeida, Agostinho
dc.contributor.authorBronze, Maria Rosário
dc.contributor.authorDelerue-Matos, Cristina
dc.contributor.authorGrosso, Clara
dc.contributor.institutionLAQV@REQUIMTE
dc.contributor.institutionDQ - Departamento de Química
dc.contributor.institutionInstituto de Tecnologia Química e Biológica António Xavier (ITQB)
dc.contributor.pblMDPI - Multidisciplinary Digital Publishing Institute
dc.date.accessioned2022-03-29T01:38:33Z
dc.date.available2022-03-29T01:38:33Z
dc.date.issued2021-05-19
dc.descriptionPO-CI-01-0145FEDER-030240
dc.description.abstractMental health and active aging are two of the main concerns in the 21st century. To search for new neuroprotective compounds, extracts of Codium tomentosum Stackhouse and Fucus vesiculosus L. were obtained through multi-step (four step) subcritical water extraction using a temperature gradient. The safety assessment of the extracts was performed by screening pharmaceutical compounds and pesticides by UHPLC-MS/MS, and iodine and arsenic levels by ICP-MS. Although the extracts were free of pharmaceutical compounds and pesticides, the presence of arsenic and high iodine contents were found in the first two extraction steps. Thus, the health-benefits were only evaluated for the fractions obtained in steps 3 and 4 from the extraction process. These fractions were tested against five brain enzymes implicated in Alzheimer’s, Parkinson’s, and major depression etiology as well as against reactive oxygen and nitrogen species, having been observed a strong enzyme inhibition and radical scavenging activities for the step 4 fractions from both seaweed species. Regarding the variation of the chemical composition during the extraction, step 1 fractions were the richest in phenolic compounds. With the increase in temperature, Maillard reaction, caramelization and thermo-oxidation occurred, and the resulting products positively affected the antioxidant capacity and the neuroprotective effects.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent1250282
dc.identifier.doi10.3390/pr9050893
dc.identifier.issn2227-9717
dc.identifier.otherPURE: 36674828
dc.identifier.otherPURE UUID: 5d1ea079-e561-4ec2-9aa7-c8c8a8f97b67
dc.identifier.otherScopus: 85106876665
dc.identifier.otherWOS: 000654478400001
dc.identifier.otherORCID: /0000-0002-6712-752X/work/128208997
dc.identifier.urihttp://hdl.handle.net/10362/135401
dc.identifier.urlhttps://www.scopus.com/pages/publications/85106876665
dc.language.isoeng
dc.peerreviewedyes
dc.relationinfo:eu-repo/grantAgreement/FCT/9471 - RIDTI/PTDC%2FOCE-ETA%2F30240%2F2017/PT
dc.relationinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F50006%2F2020/PT
dc.relationAssociated Laboratory for Green Chemistry - Clean Technologies and Processes
dc.relationAssociated Laboratory for Green Chemistry - Clean Technologies and Processes
dc.relationiNOVA4Health - Programme in Translational Medicine (iBET, CEDOC/FCM, IPOLFG e ITQB)
dc.relationiNOVA4Health - Programme in Translational Medicine (iBET, CEDOC/FCM, IPOLFG e ITQB)
dc.relationDES-ZYME: Biocatalysis in Natural Deep Eutectic Solvents.
dc.relationinfo:eu-repo/grantAgreement/FCT/Investigador FCT/IF%2F01146%2F2015%2FCP1293%2FCT0003/PT
dc.subjectBioactivities
dc.subjectEnvironmental contaminants
dc.subjectIodine
dc.subjectNeuroprotection
dc.subjectReactive nitrogen species
dc.subjectReactive oxygen species
dc.subjectSeaweeds
dc.subjectBioengineering
dc.subjectChemical Engineering (miscellaneous)
dc.subjectProcess Chemistry and Technology
dc.subjectSDG 3 - Good Health and Well-being
dc.titleMulti-step subcritical water extracts of fucus vesiculosus l. And codium tomentosum stackhouseen
dc.title.subtitleComposition, health-benefits and safetyen
dc.typejournal article
degois.publication.issue5
degois.publication.titleProcesses
degois.publication.volume9
dspace.entity.typePublication
oaire.awardNumberPTDC/OCE-ETA/30240/2017
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oaire.awardNumberUIDB/04462/2020
oaire.awardNumberUIDP/04462/2020
oaire.awardNumberIF/01146/2015/CP1293/CT0003
oaire.awardTitleAssociated Laboratory for Green Chemistry - Clean Technologies and Processes
oaire.awardTitleAssociated Laboratory for Green Chemistry - Clean Technologies and Processes
oaire.awardTitleiNOVA4Health - Programme in Translational Medicine (iBET, CEDOC/FCM, IPOLFG e ITQB)
oaire.awardTitleiNOVA4Health - Programme in Translational Medicine (iBET, CEDOC/FCM, IPOLFG e ITQB)
oaire.awardTitleDES-ZYME: Biocatalysis in Natural Deep Eutectic Solvents.
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/9471 - RIDTI/PTDC%2FOCE-ETA%2F30240%2F2017/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F50006%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F50006%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04462%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F04462%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/Investigador FCT/IF%2F01146%2F2015%2FCP1293%2FCT0003/PT
oaire.fundingStream9471 - RIDTI
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStreamInvestigador FCT
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
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project.funder.nameFundação para a Ciência e a Tecnologia
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project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccess
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